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Fig. 5.

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Fig. 5. Apoptosis and DNA fragmentation inhibition effect of Epalrestat in RA-SH-SY5Y cells. (I) Photomicrograph showing the fluoresced DNA fragments stained by DAPI on peroxide-induced apoptosis caused in RA-SHSY5Y cells. a. Control, b. H2O2, c. Epalrestat + H2O2, and d. 50 μM Epalrestat treated. H2O2 (100 μM)-treated cells showing high number of fluoresced fragmented nuclei than Epalrestat (50 μM) treatment. (II) Graphical representation showing the morphological changes caused by apoptotic cell damage and the inhibition ability of Epalrestat on H2O2-treated RA-SH-SY5Y cells. H2O2 (100 μM) exposure has provoked programmed cell death but Epalrestat (50 μM) treatment rescued the neuronal cells from oxidative cellular damage. The data are given as mean ± SD in each group. *p < 0.05 compared to control, #p < 0.05 compared to H2O2-treated group.
J. Microbiol. Biotechnol. 2021;31:867~874
© J. Microbiol. Biotechnol.