JMB

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Table. 2.

Table. 2.

Antiviral activity (IC50), cell toxicity (CC50), and selectivity index (SI) of 21 compounds selected by the secondary screening with remdesivir as a positive control.

Drug name IC50 (µM) CC50 (µM) Selectivity Index (SI)
Amodiaquine 4.6 >50 >10.9
Micafungin 12.9 >50 >3.9
Tiratricol 4.6 >50 >10.9
Loperamide hydrochloride 14.8 >50 >3.4
Thioproperazine dimesylate 13.4 41 3.1
Selexipag 8.5 >50 >5.9
Imatinib 13.9 >50 >3.6
Asenapine 13.3 >50 >3.8
Quinidine gluconate 24.2 >50 >2.1
hydroquinidine 23.8 >50 >2.1
Masitinib 14.9 47.1 3.2
Vinpocetine 8.6 >50 >5.8
Diphenylpyraline hydrochloride 42.4 >50 >1.2
Reserpine 29.2 >50 >1.7
NKH 477 12.7 >50 >3.9
Promethazine hydrochloride 19.1 >50 >2.6
Ethopropazine hydrochloride 20.3 >50 >2.5
Eltrombopag 2.0 43.8 21.9
Vemurafenib (PLX4032) 7.0 >50 >7.1
Bromhexine hydrochloride 14.4 >50 >3.5
Dibucaine hydrochloride 21.6 >50 >2.3
Remdesivir 5.0 >50 >10
J. Microbiol. Biotechnol. 2020;30:1843~1853 https://doi.org/10.4014/jmb.2009.09009
© J. Microbiol. Biotechnol.