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Table. 5.

Table. 5.

Anti-inflammatory effects of Bifidobacterium spp.

References Strain(s) Outcomes and results Discussion
Chae et al. [29] B. animalis subsp. Lactis • Shortening of colon length reduced• Pathological properties of colon by DSS treatment decreased• DSS-induced apoptosis of intestinal epithelial cell decreased• Increased TNF-α of DSS-treated mouse reduced BB12 lowered the sensitivity to colitis, induced by DSS, and reduced the apoptosis of intestinal epithelial cells. This was attributed to the reduction in TNF-α
Khokhlova et al. [30] B. bifidum, B. longum, B. breve, B. adolescentis • Inhibited IL-8 secretion of LPS-treated HT-29 cells (conditioned medium of all tested strains) Bifidobacteria controlled the signaling pathway in epithelial cells and was species-specific
Rodes et al. [31] L. rhamnosus, B. bifidum, B. longum, B. longum subsp. Infantis • Concentration of LPS decreased • TNF-α and IL-1β decreased in intestinal LPS Probiotics lowered the intestinal LPS concentration and reduced the secretion of pro-inflammatory cytokines in macrophages

DSS, dextran sodium sulfate; IL-8, interleukin 8; IL-1β, interleukin 1 beta; LPS, lipopolysaccharide; TNF-α, tumor necrosis factor-α.

J. Microbiol. Biotechnol. 2020;30:1793~1800
© J. Microbiol. Biotechnol.