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Table. 3.

Table. 3.

Antimicrobial mechanisms of Bifidobacterium spp.

References Strain(s) Outcomes and results Discussion
Wang et al. [22] B. animalis • Adhesion was reduced without any change in viability when treated with enzymes• Viability was reduced but adhesion maintained when treated with lithium chloride• Viability was reduced to zero but adhesion increased when treated with sodium metaperiodate The adhesion of bifidobacteria was determined by the substance on the outer layer of the cell wall, and not bacterial cell viability
Natividad et al. [23] B. breve • Expression of the REGIII-γ antibacterial peptide increased• Expression of REGIII-α, a human homolog of REGIII-γ, increased A correlation existed between the expression of REGIII-γ in the colon and the composition of microflora. B. breve effectively induced REGIII expression
El Kfoury et al. [24] B. longum, B. breve • Protective effect against coxsackievirus increased when bifidobacteria was cultured with viral particles• Damage to HEp-2 cells by CV-B4 E2 was inhibited when CV-B4 was preincubated with LpA of bifidobacteria The LpA-derived protein of bifidobacteria prevented CV-B4 infection. This effect was attributed to the interaction of the protein with a viral capsid protein in CAR
Fernandez-Duarte et al. [25] B. adolescentis, L. casei, L. fermentum, B. bifidum • No difference in rotavirus infectivity when pretreated with probiotic metabolites• Challenge after co-incubation of metabolites with virus; infectivity decreased Metabolites of L. casei and B. adolescentis transformed the rotavirus protein, thus reducing its ability to effectively attach to MA104 cells

CAR, coxsackievirus and adenovirus receptor; LpAs, lipoprotein aggregates.

J. Microbiol. Biotechnol. 2020;30:1793~1800
© J. Microbiol. Biotechnol.