JMB

eISSN 1738-8872
pISSN 1017-7825

Table. 2.

Table. 2.

List of phage-biocontrol approaches against A. salmonicida in aquaculture.

Bacterial strain Fish species Challenge Phages Administration (efficient MOI*) Biocontrol potential Results Reference
HER1107 Brook trout (S. fontinalis) Immersion HER 110 Immersion (1) Yes Delayed onset of furunculosis by 7 d and reduced total mortality rates from 100% to 10% [32]
Cefas 78027 Atlantic salmon (S. salar) Cohabitation or I.P. injection O, R, and B Various methods (Various MOIs**) No No protective effects were observed [193]
AS01, ATCC 27013 ND (in vitro only) ND (in vitro only) PAS-1 ND (0.1) Yes Bacterial growths were apparently retarded until 24 h [181]
AS05 Rainbow trout (O. mykiss) I.M. injection PAS-1 I.M. injection (10,000) Yes Notable protective effects with increased survival rates (0% to 30%). Neutralizing activity against PAS-1 was detected in the phage-treated fish [33]
CECT 894 Senegalese sole (S. senegalensis) Immersion AS-A Immersion (100) Yes Inhibition of bacterial growth both in the seawater and batch cultures with fish, and no mortality was observed compared to control group (36%). [34]
AS-sz ND (in vitro only) ND (in vitro only) AS-szw, AS-yj, AS-zj, AS-sw, and AS-gz ND (0.01) Yes Efficient phage cocktail was designed and its synergetic antimicrobial activity was confirmed [183]
CECT 894 ND (in vitro only) ND (in vitro only) AS-A, AS-D, and AS-E ND (100) Yes Efficient phage cocktail was designed and its synergetic antimicrobial activity was confirmed [194]
Unnamed isolate ND (in vitro only) ND (in vitro only) ASP-1 ND (0.01) Yes Bacterial growths were apparently retarded until 12 h [195]

*MOI, Multiplicity of infection.

**The exact administration methods of phages and MOIs can be found in Verner-Jeffreys et al. [193].

J. Microbiol. Biotechnol. 2020;30:1443~1457 https://doi.org/10.4014/jmb.2005.05040
© J. Microbiol. Biotechnol.