Source of diverse bioactive compounds isolated from endophytic
Host plant | Compounds | Chemical nature | Activity | Cell/Target | Ref. | |
---|---|---|---|---|---|---|
Mycoepoxydiene (1); Altiloxin A (2); Enamidin (3); Eremofortin F (4) | Mycoepoxidiene; Terpenoids; Enamidines; Sesquiterpenoids | Cytotoxic | KB (human uterine cervical carcinoma cell); MRC-5 (human lung fibroblast cell); MDA-MB-435 (human breast cancer cell) | [7] | ||
19- |
Triterpenoids | Antibacterial | [23] | |||
Homopetasinic acid (12) | Acid derivatives | Cytotoxic | [25] | |||
3-Nitropropionic acid (13) | Acid derivatives | Sub-lethal | Larvae of |
[2] | ||
Phomopsolides A-C (14-16); ( |
Pyranones | Antibiotic | [6] | |||
Phomopsisporones A-B (18-19); ( |
Cytosporones; Mycoepoxydienes; Pyranones; Cytochalasins; Melleins; Pyridine derivatives | Antibacterial; Cytotoxic | [12] | |||
Diaporphasines A-D (36-39); Meyeroguillines A, C and D (40-42); 5-Deoxybostrycoidin (43); Fusaristatin A (44) | Alkaloids | Cytotoxic | MDA-MB-435 (human breast cancer cell); HepG2 (human liver cancer cell); HCT116 (human colon cancer cell); NCI-H460 (human non-small cell lung cancer cell); MCF10A (human normal breast cell) | [21] | ||
Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate (45); Pterin-6-carboxylic acid (46); 2,6-Ditert-butyl-4-phenol (47) | Phenolics | Anti-hypercholesterolemic | hRBC (red blood cell) | [1] | ||
Phomopsin F (48) | Hexapeptides | Cytotoxic | HepG2 (human liver cancer cell) | [26] | ||
Diaporisoindoles A-E (49-53); Tenellones C and D (54-55); Diaporindenes A-D (56-59); Isoprenylisobenzofuran A (60) | Alkaloids; Benzophenones; Alkaloids | Anti-tuberculosis; LPS-activated NO production | MptpB ( |
[27] [28] |
||
Isochromophilones A-F (61-66); 5-Chloroisorotiorin (67); |
Azaphilone derivatives | Cytotoxic | ACHN; OS-RC-2; 786-O cells (human renal cancer cells) | [20] | ||
Diaporthols A and B (73-74) | Polyketides | Anti-migration | TGF- |
[16] | ||
Cytoskyrin C (75); Epicytoskyrin (76) | Bisanthraquinones | Cytotoxic | SMMC-7721 (human hepatoma cell) | [29] | ||
Acetoxydothiorelones A and B (77-78); Dothiorelones K-N (79-82); 16-Acetoxydothiorelone C (83); Dothiorelones A-C (30-32); Dothiorelones G and I (84-85); Cytosporone D (35); Pestalotiopsone B (86); Mucorisocoumarin A (87); 5-Hydroxy-7-methoxy-4,6-dimethyl-2-phenylisoindoline-1,3-dione (88); Diaporphthalide A (89); Diaporlactone A (90) | Thiorelone | Anti-fibrosis; Cytotoxicity; Anti-diabetic | MRC-5 (human lung fibroblasts cell); BGC-823 (human gastric carcinoma cell); PTP1B (protein tyrosine phosphatase 1B) | [30] | ||
Xylarolide (91); Xylarolides A and B (92-93); Diportharine A (94) | Nonenolides; Coumarins | Antioxidant; Cytotoxic | DPPH; MIAPaCa-2 (human pancreatic cancer cell); PC-3 (human prostate cancer cell) | [24] | ||
Tenllone I (95); Lithocarins B-D (96-98); Tenellone H (99); Phomopene (100) | Benzophenones; Eremophilanes; Monoterpentoids | Cytotoxic | SF-268 (human glioblastoma cell); MCF-7 (human breast cancer cell); HepG2 (human liver cancer cell); A549 (human lung adenocarcinoma cell) | [8] | ||
Diaporthichalasins A-C (101-103); Phomopsichalasin G (104); 21- |
Cytochalasins; Tetrahydroxanthone dimers | LPS-activated NO production; Anti-inflammatory cytotoxic | RAW 264.7 (murine macrophage cell) | [15] | ||
Vochysiamides A and B (111-112); 2,5-Dihydroxybenzyl alcohol (113) | Carboxiamides; Alcohols | Antibacterial; Cytotoxic | MSSA (Gram-positive); MRSA (Gram-positive); |
[5] | ||
Phomotide A (114); 4-Acetyl-3,4-dihydro-6,8-dihydroxy- 3-methoxy-5-methylisocoumarin (115) | Polyketides | - | - | [9] | ||
Eucalyptacid A (116); Eucalactam B (117); Eugenitol (118); Cytosporone C (119); 4-Hydroxyphenethyl alcohol (120); 1-(4-Hydroxyphenyl)ethane-1,2-diol (121); |
Antifungal | [31] |