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Table. 1.

Table. 1.

Source of diverse bioactive compounds isolated from endophytic Diaporthe sp. and their potential biological activities.

Diaporthe sp. Host plant Compounds Chemical nature Activity Cell/Target Ref.
Diaporthe sp. SNB-GSS10 Sabicea cinerea Mycoepoxydiene (1); Altiloxin A (2); Enamidin (3); Eremofortin F (4) Mycoepoxidiene; Terpenoids; Enamidines; Sesquiterpenoids Cytotoxic KB (human uterine cervical carcinoma cell); MRC-5 (human lung fibroblast cell); MDA-MB-435 (human breast cancer cell) [7]
Diaporthe sp. LG23 Mahonia fortunei 19-nor-Lanosta-5(10),6,8,24-tetraene-1α,3β,12β,22S-tetraol (5); 3β,5α,9α-Trihydroxy-(22E,24R)-ergosta-7,22-dien-6-one (6); 3β,5α,9α,14α-Tetrahydroxy-(22E,24R)-ergosta-7,22-dien-6-one (7); (22E,24R)-Ergosta-7,9(11),22-triene-3β,5α,6α-triol (8); Chaxine C (9); Demethylincisterol A3 (10); Volemolide (11) Triterpenoids Antibacterial Staphylococcus aureus (Gram-positive); Escherichia coli (Gram-negative); Bacillus subtilis (Gram-positive); Pseudomonas aeruginosa (Gram-negative); Streptococcus pyogenes (Gram-positive) [23]
Diaporthe sp. 1308-05 Aucuba japonica var. borealis Homopetasinic acid (12) Acid derivatives Cytotoxic Cochliobolus miyabeanus (fungus); COLO 201 (human colon adenocarcinomacell); HL60 (human promyelocytic leukemia cell) [25]
Diaporthe citri G-01 Mikania glomerata Spreng 3-Nitropropionic acid (13) Acid derivatives Sub-lethal Larvae of Diatraea saccharalis (sugarcane borer) [2]
Diaporthe maritima DAOMC628553 Picea rubens Phomopsolides A-C (14-16); (S,E )-6-(4-hydroxy-3-oxopent-1-en-1-yl)-2H-pyran-2-one (17) Pyranones Antibiotic Bacillus subtilis (Gram-positive) [6]
Phomopsis sp. PSU-H188 Hevea brasiliensis Phomopsisporones A-B (18-19); (E)-1893A (20); 1893B (21); Mycoepoxydiene (1); 2,3-Dihydromycoepoxydiene (22); Deacetylmycoepoxydiene (23); Nectriapyrone (24); Cytochalasin N (25); Diaporthalasin (26); (3R)-5-Methylmellein (27); (3R,4R)-cis-4-Hydroxy-5-methylmellein (28); (R)-(−)-5-Hydroxymethylmellein (29); Dothiorelones A-C and E (30-33); Cytosporones B and D (34-35) Cytosporones; Mycoepoxydienes; Pyranones; Cytochalasins; Melleins; Pyridine derivatives Antibacterial; Cytotoxic Staphylococcus aureus (Gram-positive); MRSA (Gram-positive); KB (human oral cavity cancer cell); MCF-7 (human breast cancer cell); Vero (kidney fibroblast cells) [12]
Diaporthe phaseolorum SKS019 Acanthus ilicifolius Diaporphasines A-D (36-39); Meyeroguillines A, C and D (40-42); 5-Deoxybostrycoidin (43); Fusaristatin A (44) Alkaloids Cytotoxic MDA-MB-435 (human breast cancer cell); HepG2 (human liver cancer cell); HCT116 (human colon cancer cell); NCI-H460 (human non-small cell lung cancer cell); MCF10A (human normal breast cell) [21]
Diaporthe arengae TATW2 Terminalia arjuna (Roxb.) Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate (45); Pterin-6-carboxylic acid (46); 2,6-Ditert-butyl-4-phenol (47) Phenolics Anti-hypercholesterolemic hRBC (red blood cell) [1]
Diaporthe toxica Lupinus sp. Phomopsin F (48) Hexapeptides Cytotoxic HepG2 (human liver cancer cell) [26]
Diaporthe sp. SYSU-HQ3 Excoecaria agallocha Diaporisoindoles A-E (49-53); Tenellones C and D (54-55); Diaporindenes A-D (56-59); Isoprenylisobenzofuran A (60) Alkaloids; Benzophenones; Alkaloids Anti-tuberculosis; LPS-activated NO production MptpB (Mycobacterium tuberculosis protein tyrosine phosphatase B); RAW 264.7 (murine macrophage cell) [27]
[28]
Diaporthe sp. SCSIO 41011 Rhizophora stylosa Isochromophilones A-F (61-66); 5-Chloroisorotiorin (67); epi-Isochromophilone (68); Isochromophilone III (69); epi-Isochromophilone III (70); 6-((1E,3E)-3,5-Dimethylhepta-1,3-dien-1-yl)-2,4-dihydroxy-3-methylbenzaldehyde (71); (2E,4E)-1-(2,6-Dihydroxy-3,5-dimethylphenyl)hexa-2,4-dien-1-one (72) Azaphilone derivatives Cytotoxic ACHN; OS-RC-2; 786-O cells (human renal cancer cells) [20]
Diaporthe sp. ECN-137 Phellodendron amurense Diaporthols A and B (73-74) Polyketides Anti-migration TGF-β1-elicited MDA-MB-231 (human breast cancer cell) [16]
Diaporthe sp. ARL-09 Anoectochilus roxburghii Cytoskyrin C (75); Epicytoskyrin (76) Bisanthraquinones Cytotoxic SMMC-7721 (human hepatoma cell) [29]
Diaporthe pseudomangiferaea Tylophora ouata Acetoxydothiorelones A and B (77-78); Dothiorelones K-N (79-82); 16-Acetoxydothiorelone C (83); Dothiorelones A-C (30-32); Dothiorelones G and I (84-85); Cytosporone D (35); Pestalotiopsone B (86); Mucorisocoumarin A (87); 5-Hydroxy-7-methoxy-4,6-dimethyl-2-phenylisoindoline-1,3-dione (88); Diaporphthalide A (89); Diaporlactone A (90) Thiorelone Anti-fibrosis; Cytotoxicity; Anti-diabetic MRC-5 (human lung fibroblasts cell); BGC-823 (human gastric carcinoma cell); PTP1B (protein tyrosine phosphatase 1B) [30]
Diaporthe sp. Datura inoxia Mill Xylarolide (91); Xylarolides A and B (92-93); Diportharine A (94) Nonenolides; Coumarins Antioxidant; Cytotoxic DPPH; MIAPaCa-2 (human pancreatic cancer cell); PC-3 (human prostate cancer cell) [24]
Diaporthe lithocarpus A740 Morinda officinalis Tenllone I (95); Lithocarins B-D (96-98); Tenellone H (99); Phomopene (100) Benzophenones; Eremophilanes; Monoterpentoids Cytotoxic SF-268 (human glioblastoma cell); MCF-7 (human breast cancer cell); HepG2 (human liver cancer cell); A549 (human lung adenocarcinoma cell) [8]
Diaporthe sp. GZU-1021 Chiromanteshaematochir Diaporthichalasins A-C (101-103); Phomopsichalasin G (104); 21-O-Deacetyl-L-696,474 (105); Cytochalasin H (106); Biatriosporin N (107); Phomopsichin B (108); Penialidin A (109); Phomoxanthone A (110) Cytochalasins; Tetrahydroxanthone dimers LPS-activated NO production; Anti-inflammatory cytotoxic RAW 264.7 (murine macrophage cell) [15]
Diapothe vochysiae LGMF1583 Vochysia divergens Vochysiamides A and B (111-112); 2,5-Dihydroxybenzyl alcohol (113) Carboxiamides; Alcohols Antibacterial; Cytotoxic MSSA (Gram-positive); MRSA (Gram-positive); Klebsiella. pneumonia (Gram-negative); A549 (human lung adenocarcinoma cell); PC-3 (human prostate cancer cell) [5]
Phomopsis sp. CFS42 Cephalotaxus fortunei Hook Phomotide A (114); 4-Acetyl-3,4-dihydro-6,8-dihydroxy- 3-methoxy-5-methylisocoumarin (115) Polyketides - - [9]
Diaporthe eucalyptorum KY-9 Melia azedarach Linn Eucalyptacid A (116); Eucalactam B (117); Eugenitol (118); Cytosporone C (119); 4-Hydroxyphenethyl alcohol (120); 1-(4-Hydroxyphenyl)ethane-1,2-diol (121); N-(2-Hydroxy-2-phenylethyl)acetamide (122); Phomopene (100) Antifungal Alternaria. solani (fungus) [31]
J. Microbiol. Biotechnol. 2021;31:493~500 https://doi.org/10.4014/jmb.2005.05012
© J. Microbiol. Biotechnol.