JMB

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Table. 2.

Table. 2.

Potential anticancer effect of gut microbiota on animal model.

Probiotic strain Animal model Induced colon cancer (carcinogen) Reported effect Ref.
Lactobacilluscasei BL23 C57BL6 mice. AOM Protected mice against CRC development; IL-22 cytokine ↓ Caspase-7, caspase-9, and Bik ↑ [24]
Lactobacillus helveticus NS8 C57BL/6 mice, (males, 4–5 weeks old). AOM+ DSS Tumour number ↓ The degree of hyperplasia ↓ NF-κB ↓ IL-10 ↑ IL-17-producing T cells ↓ [60]
Lactobacillus acidophilus Bifidobacteriumanimalis subsp. lactis F344 rats (males) AOM+ DSS Colorectal carcinogenesis ↓ Enhancing antioxidative capacity ↑ Apoptosis ↑ [64]
Enterococcus faecalis strain KH2 C57BL/6 mice AOM+ DSS DSS-induced murine experimental Colitis ↓ colitis-associated CRC ↓ [65]
L. acidophilus B. bifidum BALB/c mice 6 week - old AOM Tumor suppressor miRNAs ↑ CRC ↓ [66]
J. Microbiol. Biotechnol. 2020;30:1607~1613 https://doi.org/10.4014/jmb.2002.02032
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