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Fig. 1.

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Fig. 1. Oral gavage of Lactobacillus reuteri NK33 and/or Bifidobacterium adolescentis NK98 alleviated Escherichia coli K1-induced depression-like behaviors in mice. Effects on depression-like behaviors in the TST (A), and FST (B). Effects on IL-6 (C) and TNF-α expression (D), NF-κB activation (p-p65/p65, E), and BDNF+/NeuN+ cell populations (F) in the hippocampus. Effects on corticosterone (CORT, G) and IL-6 (H) levels in the blood. Mice were orally exposed to K1 and thereafter test agents (EC, vehicle [1% maltose]; EN33, 1 × 109 CFU/mouse/day of NK33; EN98, 1 × 109 CFU/mouse/day of NK98; EN1:1, 1 × 109 CFU/mouse/day of the (1:1) mixture of NK33 and NK98]; EN4:1, 1 × 109 CFU/ mouse/day of the (4:1) mixture of NK33 and NK98]; EN9:1, 1 × 109 CFU/mouse/day of the (9:1) mixture of NK33 and NK98]) were orally gavaged daily for 5 days. CON group was treated with vehicle instead of test agents and K1. Blood corticosterone and IL-6 levels were assayed by ELISA kits. All data were expressed as mean ± SD (n = 5). Means with same letters are not significantly different (p < 0.05).
J. Microbiol. Biotechnol. 2020;30:1222~1226 https://doi.org/10.4014/jmb.2002.02058
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