JMB

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Table. 2.

Table. 2.

High cell density bioreactor systems for monoclonal antibody production.

Type of bioreactor Cell density (Cells/mL) Period of run (Days) Advantages Disadvantages Ref.
Hollow fiber bioreactor 1-2x108 30 • Reduces serum requirement• Increase in secretary product concentration(10X to 100X)• Cells grow post fluently for months • Membrane fouling• Fiber breakage• Difficult to monitor [46][47]
Wave bioreactor 0.3-1.5x108 27 • Flexibility• Minimum time and cost • Non customisable• Restricted scale up [48]
• Fixed bed reactor• Fluidised bed reactor 5x107-1x1085X108 2424 • Easy to build• Low cost of construction,operation and maintenance • Increased vessel size and pressure drop• Erosion of internal components [49][50]
Cryogel bioreactor 1x107-1x108 55-60 • High biocompatibility• Cells are resistant to degradation• Non-toxic • Non reusable [51]
J. Microbiol. Biotechnol. 2021;31:349~357 https://doi.org/10.4014/jmb.1911.11066
© J. Microbiol. Biotechnol.