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Fig. 6.

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Fig. 6. Mutasynthesis of FK506 derivatives in ΔtcsB or ΔfbO strain with chemical feeding. (A) 36-methyl-FK506 (15) and 36-fluoro-FK520 (16) were obtained from the culture of Δ csB strain supplemented with 4-methylphenic acid and 4-fluorocrotonic acid, respectively. (B) 32-dehydroxy-FK506 (17) was obtained from the culture of ΔfkbO strain supplemented with 3-methoxycyclohexane-1-carboxylic acid.
J. Microbiol. Biotechnol. 2020;30:1~10
© J. Microbiol. Biotechnol.