Fig. 6.

Fig. 6. Engineered ∆dadX∆alr E. coli Nissle inhibits P. aeruginosa infection. The transcriptional factor LasR expresses and binds to AHL molecules produced by P. aeruginosa. LasR-AHL binding activates P_luxR, triggering the expression of pyoS5 and the E7 lysis gene. When the cell density of P. aeruginosa reaches a certain threshold, the E. coli membrane is disrupted, consequently releasing pyocin S5 and dispersin B.

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