Journal of Microbiology and Biotechnology

eISSN 1738-8872
pISSN 1017-7825

Table. 1.

Table. 1. Table 1

Synthetic bacteria-based methods for bio-therapy.

Applications		Diseases	Bacteria Strain	Description	References
Diagnosis		Colon inflammation	E. coli Nissle 1917	Thiosulfate and tetrathionate sensors	[25]
Diagnosis		Cancer	E. coli Nissle 1917	Liver metastasis detection in urine	[31]
Drug delivery		Tumor	Salmonella enterica	Secretion of hemolysin E, a pore-forming anti-tumor toxin, in synchronized cycles	[19]
		Tumor	serovar Typhimurium		[19]
		Chronic inflammatory bowel disease	Lactococcus lactis	Secretion of monovalent and bivalent murine (m)TNF-neutralizing antibodies	[14]
		Colon inflammation	Bacteroides ovatus	Secretion of human keratinocyte growth factor-2	[38]
Treatment	Infectious diseases	Vibrio cholerae infection	E. coli Nissle 1917	Inhibit infection by producing cholera autoinducer 1 (CAI-1) (assisted by AI-2) showing a survival rate of 92%	[45]
		Pseudomonas	E. coli Nissle 1917	Inhibit infection by producing pyocin S5 (assisted by AHLs and E7 lysis protein) showing a survival rate of 99%	[47, 48]
		aeruginosa gut infection	E. coli Nissle 1917		[47, 48]
		Chlamydia trachomatis infection	M13 bacteriophage	Inhibit infection by producing integrin binding peptide (RGD) and a segment of the polymorphic membrane protein D (PmpD)	[18]
	Metabolic diseases	Type 1 diabetes	Lactococcus lactis	Preservation of β-cells through production of T1D autoantigen GAD65370–575 and anti-inflammatory cytokine IL-10	[50]
		Obesity	E. coli Nissle 1917	Embedding of N-acylphosphatidylethanolamines (NAPEs)-synthesizing enzyme to reduce food uptake for treatment of obesity.	[53]
		Cancer	Attenuated	Colonizes tumor by expressing an RGD motif fused within the transmembrane protein OmpA, subsequently suppressing tumor growth by the release of TNF-α and IL-1β	[56]
			Salmonella
			typhimurium

J. Microbiol. Biotechnol. 2019;29:845~855 https://doi.org/10.4014/jmb.1904.04016

© J. Microbiol. Biotechnol.