Journal of Microbiology and Biotechnology
The Korean Society for Microbiology and Biotechnology publishes the Journal of Microbiology and Biotechnology.
Journal of Microbiology and Biotechnology
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2013 ; 23(7): 1041~1045

AuthorEric C. Claas, Carey-Ann D. Burnham, Tony Mazzulli, Kate Templeton, Francois Topin
AffiliationDepartment of Medical Microbiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands
TitlePerformance of the xTAG® Gastrointestinal Pathogen Panel, a Multiplex Molecular Assay for Simultaneous Detection of Bacterial, Viral, and Parasitic Causes of Infectious Gastroenteritis
PublicationInfo J. Microbiol. Biotechnol.2013 ; 23(7): 1041~1045
AbstractThe xTAG® Gastrointestinal Pathogen Panel (GPP) is a multiplexed molecular test for 15 gastrointestinal pathogens. The sensitivity and specificity of this test were assessed in 901 stool specimens collected from pediatric and adult patients at four clinical sites. A combination of conventional and molecular methods was used as comparator. Sensitivity could be determined for 12 of 15 pathogens and was 94.3% overall. The specificity across all 15 targets was 98.5%. Testing for the pathogen identified was not requested by the physician in 65% of specimens. The simultaneous detection of these 15 pathogens can provide physicians with a more comprehensive assessment of the etiology of diarrheal disease.
KeywordsLuminex, xTAG GPP, multiplex, gastroenteritis, infectious diarrhea
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