2013 ; 23(7):
|Author||Eric C. Claas, Carey-Ann D. Burnham, Tony Mazzulli, Kate Templeton, Francois Topin|
|Affiliation||Department of Medical Microbiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands|
|Title||Performance of the xTAG® Gastrointestinal Pathogen Panel, a Multiplex Molecular Assay for Simultaneous Detection of Bacterial, Viral, and Parasitic Causes of Infectious Gastroenteritis|
J. Microbiol. Biotechnol.2013 ; 23(7):
|Abstract||The xTAG® Gastrointestinal Pathogen Panel (GPP) is a multiplexed molecular test for 15
gastrointestinal pathogens. The sensitivity and specificity of this test were assessed in 901
stool specimens collected from pediatric and adult patients at four clinical sites. A
combination of conventional and molecular methods was used as comparator. Sensitivity
could be determined for 12 of 15 pathogens and was 94.3% overall. The specificity across all 15
targets was 98.5%. Testing for the pathogen identified was not requested by the physician in
65% of specimens. The simultaneous detection of these 15 pathogens can provide physicians
with a more comprehensive assessment of the etiology of diarrheal disease.|
|Keywords||Luminex, xTAG GPP, multiplex, gastroenteritis, infectious diarrhea|
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