2013 ; 23(5):
|Author||Jeongmin Lee, Jieun Bang, Hee-Jong Woo|
|Affiliation||Laboratory of Immunology, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea,Division of Zoonoses, Center for Immunology and Pathology, National Institute of Health, Korea Centers for Disease Control and Prevention, Cheongwon-gun, Chungcheongbuk-do 363-951, Korea|
|Title||Immunomodulatory and Anti-Allergic Effects of Orally Administered Lactobacillus Species in Ovalbumin-Sensitized Mice|
J. Microbiol. Biotechnol.2013 ; 23(5):
|Abstract||We investigated the effects of orally administered probiotic
bacteria (Lactobacillus species) as allergic immune modulators
in ovalbumin (OVA)-sensitized mice. BALB/c mice were
intraperitoneally injected with OVA twice at a 2-week
interval for allergy sensitization. The mice were then
orally administered Lactobacillus casei YIT9029 (L1), L.
casei HY7201 (L2), L. brevis HY7401 (L3), or L. plantarum
HY20301 (L4) every 2 days for 3 weeks. Total IgE levels
significantly decreased in sera of L3-administered mice
but increased in the other groups. OVA-specific IgE levels
decreased slightly in sera of mice administered L1, L3,
and L4 but increased significantly in L2-administered
mice. In passive cutaneous anaphylaxis (PCA) using sera
from administered mice, only the L3-administered group
showed reaction inhibition. High expression of TLR-2
with interferon (IFN)-γ stimulation on peripheral blood
mononuclear cells occurred in L3- or L4-administered
mice. Th1 cytokines, including IFN-γ and interleukin (IL)-
12, increased in splenocytes of L3-administered mice;
however, IL-4 decreased in L1- and L4-administered groups;
IL-5 decreased in all experimental groups. IL-6 decreased
in the L3-administered group; and IL-10 decreased in
L1-, L2-, and L3-administered groups. L3 induced antiallergic
effects by increasing Th1 cytokines, decreasing
Th2 cytokines, and inhibiting the PCA reaction, whereas
L2 administration increased allergic effects.|
|Keywords||allergy, oral administration, probiotics, Lactobacillus|
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