2012 ; 22(11):
|Author||Lifeng Zan, Haiying Bao, Tolgor Bau, Hanbin Liu, Baokai Cui|
|Affiliation||Engineering Research Centre of Edible and Medicinal Fungi, Ministry of Education, Jilin Agricultural University, Changchun, Jilin 130118, P. R. China |
|Title||An Antitumor Component from Fomitiporia ellipsoidea|
J. Microbiol. Biotechnol.2012 ; 22(11):
|Abstract||A natural furan derivative was isolated from the methanolic
extract of the fruit bodies of Fomitiporia ellipsoidea. Its
chemical structure was elucidated as methyl 3,5-dioxo-
by means of extensive NMR and MS data analysis, and
named as fomitiporiaester A (1). Compound 1 showed
significant antitumor activity to hepatoma H22 in vivo, and
the inhibition rates were 42.94%, 49.17%, and 58.15%
at concentrations of 5, 10, and 20 mg/kg, respectively.
Compound 1 showed weak cytotoxic activities against the
human hepatoblastoma (HepG-2) and human oophoroma
(Skov 3) cell lines with IC50 values of more than 100 μM.|
|Keywords||Fomitiporia ellipsoidea, furan ester, antitumor|
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