Journal of Microbiology and Biotechnology
The Korean Society for Microbiology and Biotechnology publishes the Journal of Microbiology and Biotechnology.
Journal of Microbiology and Biotechnology
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2012 ; 22(11): 1482~1485

AuthorLifeng Zan, Haiying Bao, Tolgor Bau, Hanbin Liu, Baokai Cui
AffiliationEngineering Research Centre of Edible and Medicinal Fungi, Ministry of Education, Jilin Agricultural University, Changchun, Jilin 130118, P. R. China
TitleAn Antitumor Component from Fomitiporia ellipsoidea
PublicationInfo J. Microbiol. Biotechnol.2012 ; 22(11): 1482~1485
AbstractA natural furan derivative was isolated from the methanolic extract of the fruit bodies of Fomitiporia ellipsoidea. Its chemical structure was elucidated as methyl 3,5-dioxo- 1,3,5,7-tetrahydrobenzo[1,2-c:4,5-c']difuran-4-carboxylate by means of extensive NMR and MS data analysis, and named as fomitiporiaester A (1). Compound 1 showed significant antitumor activity to hepatoma H22 in vivo, and the inhibition rates were 42.94%, 49.17%, and 58.15% at concentrations of 5, 10, and 20 mg/kg, respectively. Compound 1 showed weak cytotoxic activities against the human hepatoblastoma (HepG-2) and human oophoroma (Skov 3) cell lines with IC50 values of more than 100 μM.
KeywordsFomitiporia ellipsoidea, furan ester, antitumor
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