Journal of Microbiology and Biotechnology
The Korean Society for Microbiology and Biotechnology publishes the Journal of Microbiology and Biotechnology.
Journal of Microbiology and Biotechnology
Condition  Expression
When you enter More than two words, please use ‘and , or’ operation by means of putting ‘,(Comma Mark)’ between each word.

2010 ; 20(5): 942~945

AuthorKazuko Okamoto-Shibayama, Yutaka Sato, Toshifumi Azuma
AffiliationDepartment of Biochemistry and Oral Health Science Center HRC7, Tokyo Dental College; 1-2-2 Masago, Mihama-ku, Chiba City,261-8502, Japan
TitleResveratrol Impaired the Morphological Transition of Candida albicans Under Various Hyphae-inducing Conditions
PublicationInfo J. Microbiol. Biotechnol.2010 ; 20(5): 942~945
AbstractThe ability of the human fungal pathogen Candida albicans to undergo the morphological transition from a single yeast form to pseudohyphal and hyphal forms in response to various conditions is known to be an important for its virulence. Many studies have shown the pharmacological effects of resveratrol, a phytoalexin polyphenolic compound. In this study, we investigated the antifungal activity of resveratrol against C. albicans. Both yeast-form and mycelial growth of C. albicans were inhibited by resveratrol. In addition, normal filamentation of C. albicans was affected and yeast-to-hypha transition under serum-, pH-, and nutrient-induced hyphal growth conditions was impaired by resveratrol.
Full-Text(PDF)
KeywordsCandida albicans, resveratrol (trans-3,4’,-5-trihydroxystilebene), dimorphism
References
1. Abe, S., Y. Sato, S. Inoue, H. Ishibashi, N. Maruyama, T. Takizawa, H. Oshima, and H. Yamaguchi. 2003 Anti-Candida albicans activity of essential oils including lemongrass (Cymbopogon citratus) oil and its component, citral. Nippon Ishinkin Gakkai Zasshi 44: 285-291.  : -


2. Abe, S., Y. Sato, S. Inoue, H. Ishibashi, N. Maruyama, T. Takizawa, H. Oshima, and H. Yamaguchi. 2003 Anti-Candida albicans activity of essential oils including lemongrass (Cymbopogon citratus) oil and its component, citral. Nippon Ishinkin Gakkai Zasshi 44: 285-291.  : -


3. Abe, S., T. Satoh, Y. Tokuda, S. Tansho, and H. Yamaguchi. 1994 A rapid colorimetric assay for determination of leukocytemediated inhibition of mycelial growth of Candida albicans. Microbiol. Immunol. A rapid colorimetric assay for determination of leukocytemediated inhibition of mycelial growth of Candida albicans. Microbiol. 38: 385-388


4. Abe, S., T. Satoh, Y. Tokuda, S. Tansho, and H. Yamaguchi. 1994 A rapid colorimetric assay for determination of leukocytemediated inhibition of mycelial growth of Candida albicans. Microbiol. Immunol. A rapid colorimetric assay for determination of leukocytemediated inhibition of mycelial growth of Candida albicans. Microbiol. 38: 385-388


5. Baur, J. A. and D. A. Sinclair. 2006 Therapeutic potential of resveratrol: The in vivo evidence. Nat. Rev. Drug Discov. Therapeutic potential of resveratrol: The in vivo evidence. Nat. Rev. 5: 493-506


6. Baur, J. A. and D. A. Sinclair. 2006 Therapeutic potential of resveratrol: The in vivo evidence. Nat. Rev. Drug Discov. Therapeutic potential of resveratrol: The in vivo evidence. Nat. Rev. 5: 493-506


7. Bhat, K. P. and J. M. Pezzuto. 2002 Cancer chemopreventive activity of resveratrol. Ann. NY Acad. Sci. Cancer chemopreventive activity of resveratrol. Ann. NY Acad. 957: 210-229


8. Bhat, K. P. and J. M. Pezzuto. 2002 Cancer chemopreventive activity of resveratrol. Ann. NY Acad. Sci. Cancer chemopreventive activity of resveratrol. Ann. NY Acad. 957: 210-229


9. de Repentigny, L., D. Lewandowski, and P. Jolicoeur. 2004 Immunopathogenesis of oropharyngeal candidiasis in human immunodeficiency virus infection. Clin. Microbiol. Rev. Immunopathogenesis of oropharyngeal candidiasis in human immunodeficiency virus infection. Clin. Microbiol. 17: 729-759


10. de Repentigny, L., D. Lewandowski, and P. Jolicoeur. 2004 Immunopathogenesis of oropharyngeal candidiasis in human immunodeficiency virus infection. Clin. Microbiol. Rev. Immunopathogenesis of oropharyngeal candidiasis in human immunodeficiency virus infection. Clin. Microbiol. 17: 729-759


11. Docherty, J. J., M. M. Fu, and M. Tsai. 2001 Resveratrol selectively inhibits Neisseria gonorrhoeae and Neisseria meningitidis. J. Antimicrob. Chemother. Resveratrol selectively inhibits Neisseria gonorrhoeae and Neisseria meningitidis. J. Antimicrob. 47: 243-244


12. Docherty, J. J., M. M. Fu, and M. Tsai. 2001 Resveratrol selectively inhibits Neisseria gonorrhoeae and Neisseria meningitidis. J. Antimicrob. Chemother. Resveratrol selectively inhibits Neisseria gonorrhoeae and Neisseria meningitidis. J. Antimicrob. 47: 243-244


13. Donnelly, L. E., R. Newton, G. E. Kennedy, P. S. Fenwick, R. H. Leung, K. Ito, R. E. Russell, and P. J. Barnes. 2004 Antiinflammatory effects of resveratrol in lung epithelial cells: Molecular mechanisms. Am. J. Physiol. Lung Cell Mol. Physiol. 287: L774-L783.  : -


14. Donnelly, L. E., R. Newton, G. E. Kennedy, P. S. Fenwick, R. H. Leung, K. Ito, R. E. Russell, and P. J. Barnes. 2004 Antiinflammatory effects of resveratrol in lung epithelial cells: Molecular mechanisms. Am. J. Physiol. Lung Cell Mol. Physiol. 287: L774-L783.  : -


15. Hawser, S. 1996 Comparisons of the susceptibilities of planktonic and adherent Candida albicans to antifungal agents: A modified XTT tetrazolium assay using synchronised C. albicans cells. J. Med. Vet. Mycol. Comparisons of the susceptibilities of planktonic and adherent Candida albicans to antifungal agents: A modified XTT tetrazolium assay using synchronised C. alb 34: 149-152


16. Hawser, S. 1996 Comparisons of the susceptibilities of planktonic and adherent Candida albicans to antifungal agents: A modified XTT tetrazolium assay using synchronised C. albicans cells. J. Med. Vet. Mycol. Comparisons of the susceptibilities of planktonic and adherent Candida albicans to antifungal agents: A modified XTT tetrazolium assay using synchronised C. alb 34: 149-152


17. Ignatowicz, E. and W. Baer-Dubowska. 2001 Resveratrol, a natural chemopreventive agent against degenerative diseases. Pol. J. Pharmacol. Resveratrol, a natural chemopreventive agent against degenerative diseases. Pol. J. 53: 557-569


18. Ignatowicz, E. and W. Baer-Dubowska. 2001 Resveratrol, a natural chemopreventive agent against degenerative diseases. Pol. J. Pharmacol. Resveratrol, a natural chemopreventive agent against degenerative diseases. Pol. J. 53: 557-569


19. Jung, H. J., I. A. Hwang, W. S. Sung, H. Kang, B. S. Kang, Y. B. Seu, and D. G. Lee. 2005 Fungicidal effect of resveratrol on human infectious fungi. Arch. Pharm. Res. Fungicidal effect of resveratrol on human infectious fungi. Arch. Pharm. 28: 557-560


20. Jung, H. J., I. A. Hwang, W. S. Sung, H. Kang, B. S. Kang, Y. B. Seu, and D. G. Lee. 2005 Fungicidal effect of resveratrol on human infectious fungi. Arch. Pharm. Res. Fungicidal effect of resveratrol on human infectious fungi. Arch. Pharm. 28: 557-560


21. Jung, H. J., Y. B. Seu, and D. G. Lee. 2007 Candicidal action of resveratrol isolated from grapes on human pathogenic yeast C. albicans. J. Microbiol. Biotechnol. Candicidal action of resveratrol isolated from grapes on human pathogenic yeast C. albicans. J. Microbiol. 17: 1324-1329


22. Jung, H. J., Y. B. Seu, and D. G. Lee. 2007 Candicidal action of resveratrol isolated from grapes on human pathogenic yeast C. albicans. J. Microbiol. Biotechnol. Candicidal action of resveratrol isolated from grapes on human pathogenic yeast C. albicans. J. Microbiol. 17: 1324-1329


23. Kanafani, Z. A. and J. R. Perfect. 2008 Antimicrobial resistance: Resistance to antifungal agents: Mechanisms and clinical impact. Clin. Infect. Dis. Antimicrobial resistance: Resistance to antifungal agents: Mechanisms and clinical impact. Clin. Infect. 46: 120-128


24. Kanafani, Z. A. and J. R. Perfect. 2008 Antimicrobial resistance: Resistance to antifungal agents: Mechanisms and clinical impact. Clin. Infect. Dis. Antimicrobial resistance: Resistance to antifungal agents: Mechanisms and clinical impact. Clin. Infect. 46: 120-128


25. Lee, S. K., H. J. Lee, H. Y. Min, E. J. Park, K. M. Lee, Y. H. Ahn, Y. J. Cho, and J. H. Pyee. 2005 Antibacterial and antifungal activity of pinosylvin, a constituent of pine. Fitoterapia 76: 258-260.  : -


26. Lee, S. K., H. J. Lee, H. Y. Min, E. J. Park, K. M. Lee, Y. H. Ahn, Y. J. Cho, and J. H. Pyee. 2005 Antibacterial and antifungal activity of pinosylvin, a constituent of pine. Fitoterapia 76: 258-260.  : -


27. Li, Y., C. Su, X. Mao, F. Cao, and J. Chen. 2007 Roles of Candida albicans Sfl1 in hyphal development. Eukaryot. Cell 6: 2112-2121.  : -


28. Li, Y., C. Su, X. Mao, F. Cao, and J. Chen. 2007 Roles of Candida albicans Sfl1 in hyphal development. Eukaryot. Cell 6: 2112-2121.  : -


29. Lo, H. J., J. R. Kohler, B. DiDomenico, D. Loebenberg, A. Cacciapuoti, and G. R. Fink. 1997 Nonfilamentous C. albicans mutants are avirulent. Cell 90: 939-949.  : -


30. Lo, H. J., J. R. Kohler, B. DiDomenico, D. Loebenberg, A. Cacciapuoti, and G. R. Fink. 1997 Nonfilamentous C. albicans mutants are avirulent. Cell 90: 939-949.  : -


31. Odds, F. C. 1987 Candida infections: An overview. Crit. Rev. Microbiol. Candida infections: An overview. Crit. Rev. 15: 1-5


32. Odds, F. C. 1987 Candida infections: An overview. Crit. Rev. Microbiol. Candida infections: An overview. Crit. Rev. 15: 1-5


33. Ogasawara, A., N. Komaki, H. Akai, K. Hori, H. Watanabe, T. Watanabe, T. Mikami, and T. Matsumoto. 2007 Hyphal formation of Candida albicans is inhibited by salivary mucin. Biol. Pharm. Bull. Hyphal formation of Candida albicans is inhibited by salivary mucin. Biol. Pharm. 30: 284-286


34. Ogasawara, A., N. Komaki, H. Akai, K. Hori, H. Watanabe, T. Watanabe, T. Mikami, and T. Matsumoto. 2007 Hyphal formation of Candida albicans is inhibited by salivary mucin. Biol. Pharm. Bull. Hyphal formation of Candida albicans is inhibited by salivary mucin. Biol. Pharm. 30: 284-286


35. Sudbery, P., N. Gow, and J. Berman. 2004 The distinct morphogenic states of Candida albicans. Trends Microbiol. The distinct morphogenic states of Candida albicans. 12: 317-324


36. Sudbery, P., N. Gow, and J. Berman. 2004 The distinct morphogenic states of Candida albicans. Trends Microbiol. The distinct morphogenic states of Candida albicans. 12: 317-324


37. Sanchez-Martinez, C. and J. Perez-Martin. 2002 Site-specific targeting of exogenous DNA into the genome of Candida albicans using the FLP recombinase. Mol. Genet. Genomics 268: 418-424.  : -


38. Sanchez-Martinez, C. and J. Perez-Martin. 2002 Site-specific targeting of exogenous DNA into the genome of Candida albicans using the FLP recombinase. Mol. Genet. Genomics 268: 418-424.  : -


39. Watamoto, T., L. P. Samaranayake, J. A. Jayatilake, H. Egusa, H. Yatani, and C. J. Seneviratne. 2009 Effect of filamentation and mode of growth on antifungal susceptibility of Candida albicans. Int. J. Antimicrob. Agents 34: 333-339.  : -


40. Watamoto, T., L. P. Samaranayake, J. A. Jayatilake, H. Egusa, H. Yatani, and C. J. Seneviratne. 2009 Effect of filamentation and mode of growth on antifungal susceptibility of Candida albicans. Int. J. Antimicrob. Agents 34: 333-339.  : -


41. Weber, K., B. Schulz, and M. Ruhnke. 2009 Resveratrol and its antifungal activity against Candida species. Mycoses [In Press.]  : -


42. Weber, K., B. Schulz, and M. Ruhnke. 2009 Resveratrol and its antifungal activity against Candida species. Mycoses [In Press.]  : -


Copyright © 2009 by the Korean Society for Microbiology and Biotechnology.
All right reserved. Mail to jmb@jmb.or.kr
Online ISSN: 1738-8872    Print ISSN: 1017-7825    Powered by INFOrang.co., Ltd