Journal of Microbiology and Biotechnology
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2010 ; 20(1): 5~14

AuthorJi Youn Lim, JangWon Yoon, Carolyn J. Hovde
AffiliationDepartment of Microbiology, Molecular Biology, and Biochemistry, University of Idaho, Moscow, Idaho 83844, USA
TitleA Brief Overview of Escherichia coli O157:H7 and Its Plasmid O157
PublicationInfo J. Microbiol. Biotechnol.2010 ; 20(1): 5~14
AbstractEnterohemorrhagic Escherichia coli O157:H7 is a major food-borne pathogen causing severe disease in humans worldwide. Healthy cattle are a reservoir of E. coli O157:H7 and bovine food products and fresh produce contaminated with bovine waste are the most common sources for disease outbreaks in the United States. E. coli O157:H7 also survives well in the environment. The ability to cause human disease, colonize the bovine gastrointestinal tract, and survive in the environment, requires that E. coli O157:H7 adapt to a wide variety of conditions. Three major virulence factors of E. coli O157:H7 have been identified including Shiga toxins, a pathogenicity island called the locus of enterocyte effacement, and an F-like plasmid, pO157. Among these virulence factors, the role of the pO157 is least understood. This review provides a board overview of E. coli O157:H7 with an emphasis on the pO157.
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KeywordsE. coli O157:H7, pO157
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