Journal of Microbiology and Biotechnology
The Korean Society for Microbiology and Biotechnology publishes the Journal of Microbiology and Biotechnology.
Journal of Microbiology and Biotechnology
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2008 ; 18(9): 1485~1491

AuthorCundliffe, Eric
TitleControl of Tylosin Biosynthesis in Streptomyces fradiae
PublicationInfo J. Microbiol. Biotechnol.2008 ; 18(9): 1485~1491
AbstractTylosin biosynthesis is controlled in cascade fashion by multiple transcriptional regulators, acting positively or negatively, in conjunction with a signalling ligand that acts as a classical inducer. The roles of regulatory gene products have been characterized by a combination of gene expression analysis and fermentation studies, using engineered strains of S. fradiae in which specific genes were inactivated or overexpressed. Among various novel features of the regulatory model, involvement of the signalling ligand is not essential for tylosin biosynthesis.
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KeywordsAntibiotic production, gamma-butyrolactone, gene regulation, Streptomyces, tylosin
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