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 2008 ; 18(8):
1482~1484
| Author | Kim, Keuk-Jun, Woo Sang Sung, Seok-Ki Moon, Jong-Soo Choi, Jong Guk Kim, Dong Gun Lee |
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| Title | Antifungal Effect of Silver Nanoparticles on Dermatophytes |
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| PublicationInfo |
J. Microbiol. Biotechnol.2008 ; 18(8):
1482~1484 |
| Abstract | Spherical silver nanoparticles (nano-Ag) were synthesized and their antifungal effects on fungal pathogens of the skin were investigated. Nano-Ag showed potent activity against clinical isolates and ATCC strains of Trichophyton mentagrophytes and Candida species ($IC_{80}$, 1-7${\mu}g/ml$). The activity of nano-Ag was comparable to that of amphotericin B, but superior to that of fluconazole (amphotericin B $IC_{80}$, 1-5${\mu}g/ml$; fluconazole $IC_{80}$, 10-30${\mu}g/ml$). Additionally, we investigated their effects on the dimorphism of Candida albicans. The results showed nano-Ag exerted activity on the mycelia. Thus, the present study indicates nano-Ag may have considerable antifungal activity, deserving further investigation for clinical applications. |
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| Keywords | Silver nanoparticles, antifungal effect, Trichophyton mentagrophytes, Candida species |
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