|
|
|
 2007 ; 17(5):
858~864
| Author | Cha, Jeong-Dan, Mi-Ran Jeong, Seung-Il Jeong, Kyung-Yeol Lee |
|---|
| Title | Antibacterial Activity of Sophoraflavanone G Isolated from the Roots of Sophora flavescens |
|---|
| PublicationInfo |
J. Microbiol. Biotechnol.2007 ; 17(5):
858~864 |
| Abstract | This study investigated the antibacterial activities of sophoraflavanone G from Sophora flavescens in combination with two antimicrobial agents against oral bacteria. The combined effect of sophoraflavanone G and the antimicrobial agents was evaluated using the checkerboard method to obtain a fractional inhibitory concentration(FIC) index. The sophoraflavanone G+ampicillin(AM) combination was found to have a synergistic effect against S. mutans, S. sanguinis, S. sobrinus, S. gordonii, A. actinomycetemcomitans, F nucleatum, P. intermedia, and P. gingivalis, whereas the sophoraflavanone G+gentamicin(GM) combination had a synergistic effect against S. sanguinis, S. criceti, S. anginosus, A. actinomycetemcomitans, F nucleatum, P. intermedia, and P. gingivalis. Neither combination exhibited any antagonistic interactions(FIC index>4). In particular, the MICs/MBCs for all the bacteria were reduced to one-half$\sim$one-sixteenth as a result of the drug combinations. A synergistic interaction was also confirmed by time-kill studies for nine bacteria where the checkerboard suggested synergy. Thus, a strong bactericidal effect was exerted through the drug combinations, plus in vitro data suggested that sophoraflavanone G combined with other antibiotics may be microbiologically beneficial rather than antagonistic. |
|---|
| Full-Text(PDF) |  |
|---|
| Keywords | Sophora flavescens, sophoraflavanone G, antibacterial activity, checkerboard method, time-kill method, synergic effect |
|---|
|
|
|
|
