2018 ; 28(8):
|Author||Yun-A Park, Sung Ryul Lee, Jin Woo Lee, Hyun Jung Koo, Seon-A Jang, Seung-Won Yun, Hyun Ju Kim, Jeong Suk Woo, Myung Rye Park, Se Chan Kang, Youn Kyu Kim, Eun-Hwa Sohn|
|Affiliation||Department of Herbal Medicine Resource, Kangwon National University, Samcheok 25949, Republic of Korea|
|Title||Suppressive Effect of Fermented Angelica tenuissima Root Extract against Photoaging: Possible Involvement of Hemeoxygenase-1|
J. Microbiol. Biotechnol.2018 ; 28(8):
|Abstract||Angelica tenuissima root has historically been used as a traditional medicine in Korea. Previous
studies have identified the anti-melanogenic effects of the extract of A. tenuissima root
fermented by Aspergillus oryzae (FAT). This study investigated the protective effects of FAT
against ultraviolet light B exposure (UVB; 30 mJ/cm2) in HaCaT (human keratinocyte) or Hs68
(human foreskin fibroblast) skin cells. FAT treatment was able to stimulate wound healing rate
at the basal condition. FAT also favored the maintenance and/or improvement of extracellular
matrix impairment caused by UVB irradiation through: 1) upregulation of procollagen Type-1
synthesis and secretion; 2) suppression of MMP-1 and elastase expression. FAT was able to
play a role in the attenuation of inflammatory responses caused by UVB irradiation via
upregulation of photo-protective hemeoxygease-1 and suppression of proinflammatory
cyclooxygenase-2 expression. After further verification of the anti-photoaging potential of
FAT, it could be utilized as an effective ingredient in anti-aging and anti-wrinkle cosmetics.|
|Keywords||Angelica tenuissima, photoaging, fermentation, ultraviolet light B, hemeoxygenase-1, extracellular matrix|
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