2016 ; 26(5):
|Author||Jungman Kim, Robin Becina Guevarra, Son Giang Nguyen, Ji-Hoon Lee, Dong Kee Jeong, Tatsuya Unno|
|Affiliation||Faculty of Biotechnology, College of Applied Life Science, SARI, Jeju National University, Jeju 63243, Republic of Korea|
|Title||Effects of the Antibiotics Growth Promoter Tylosin on Swine Gut Microbiota|
J. Microbiol. Biotechnol.2016 ; 26(5):
|Abstract||Tylosin has been used as a livestock feed additive and antibiotic growth promoter for many
years. However, the mode of action by which tylosin enhances animal growth is unclear. We
used high-throughput sequencing of 16S rRNA genes to investigate the effects of tylosin as a
feed additive on swine gut microbiota. No significant difference in the rate of weight increase
was observed between control and tylosin-treated pigs during a 10-week feeding trial.
However, tylosin-treated pigs showed rapid increases in the relative abundance of the phylum
Firmicutes. Increases in Firmicutes species are associated with (so-called) obese-type gut
microbiota. The abundance of species of four families of the phylum Firmicutes
(Streptococcaceae, Peptococcaceae, Peptostreptococcaceae, and Clostridiaceae) correlated positively with host weight gain. The abundance of Streptococcaceae family bacteria was least affected by
tylosin treatment. Distribution analysis of operational taxonomic units (OTUs) showed that
both control and tylosin-treated pigs exhibited similar OTU alterations during growth.
However, the tylosin-treated group showed distinctive alterations in gut microbiota when the
host weighed approximately 60 kg, whereas similar alterations occurred at around 80 kg in the
control group. Our results suggest that use of tylosin accelerates maturation of swine gut
microbiota rather than altering its composition.|
|Keywords||16S rRNA gene, antibiotics, growth promoter, swine gut microbiota, tylosin|
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