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ReviewFood Biotechnology (FB) | Bioactive compounds and Physiological properties
Marine Algicolous Endophytic Fungi - A Promising Drug Resource of the Era
1Department of Marine Biology, Microbiology, and Biochemistry, School of Marine Sciences, Cochin University of Science and Technology, Kochi-682016, Kerala, India, 2Department of Biological Science, College of Science, Sungkyunkwan University, Suwon 16419, Republic of KoreaReceived: January 13, 2017; Accepted: April 3, 2017
J. Microbiol. Biotechnol. 2017; 27(6): 1039-1052
Published June 28, 2017
Copyright © The Korean Society for Microbiology and Biotechnology.
AbstractEndophytic fungi have currently been acknowledged as the most promising source of bioactive compounds for drug discovery, and considerable progress has been made in exploring their diversity, species richness, and bioprospecting. Fungal endophytes from unique environmental settings offer a pool of potentially useful medicinal entities. Owing to the constant stresses imposed on macroalgae by marine environments, it is believed that algae and their associated endophytic symbionts represent a good source of structurally diverse bioactive secondary metabolites. Despite the proven significance of active metabolites of algal endophytes, little have been exploited. This review highlights the latest discoveries in algicolous endophytic research, with particular focus on the bioactive metabolites from algal endophytes. Compounds are classified according to their reported biological activities, like anticancer, antibacterial, antifungal, and antioxidant properties. Present experimental evidence suggests that a majority of the bioactive metabolites were reported from Phaeophyceae followed by Rhodophyceae and Chlorophyceae. An intensive search for newer and more effective bioactive metabolites has generated a treasure trove of publications, and this review partially covers the literature published up to 2016.
KeywordsMacroalgae, endophytic fungi, secondary metabolite, bioactive compound, anticancer, antimicrobial