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ReviewBioprocess and Metabolic Engineering
Recent Insights in the Removal of Klebseilla Pathogenicity Factors for the Industrial Production of 2,3-Butanediol
1Institute of Life Sciences and Resources, and Department of Food Science and Biotechnology, College of Life Sciences, Kyung Hee University, Yongin 446-701, Republic of Korea, 2Department of Chemical and Biomolecular Engineering, Sogang University, Seoul 121-742, Republic of KoreaReceived: February 27, 2013; Accepted: March 18, 2013
J. Microbiol. Biotechnol. 2013; 23(7): 885-896
Published July 28, 2013
Copyright © The Korean Society for Microbiology and Biotechnology.
Abstract2,3-Butanediol (2,3-BDO) has immense industrial applications. Recently, microbial fermentation has emerged as an alternative way to produce this industrially important chemical. Although 2,3-BDO is produced by several microorganisms, the Klebsiella genera has an excellent production compared with other 2,3-BDO-producing microorganisms. In order to produce 2,3- BDO on a large scale, the challenges of removing pathogenic factors from Klebsiella pneumoniae need to be addressed. K. pneumoniae produces a number of virulence factors that contribute to its pathogenesis, including lipopolysaccharides, capsules, fimbrial adhesins, etc. Removal of these pathogenic factors from 2,3-BDO-producing Klebsiella strains will result in avirulent strains for the safe, economic, and efficient production of 2,3-BDO. In this review, we summarize the current trends in 2,3-BDO production using K. pneumoniae and insights into the removal of its virulence factors for industrial applications.
Keywords2,3-Butanediol, K. pneumoniae, fimbriae, lipopolysaccharide, pathogenic factors, lipopolysaccharide