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Antimicrobial Effects of Flavone Analogues and Their Structure-Activity Relationships
Bio/Molecular Informatics Center, Department of Bioscience and Biotechnology, IBST, Konkuk University, Seoul 143-701, Korea
J. Microbiol. Biotechnol. 2007; 17(3): 530-533
Published March 28, 2007
Copyright © The Korean Society for Microbiology and Biotechnology.
AbstractIt has been well known that the use of Saccharomyces cerevisiae can cause fungemia in critically ill patients and flavone shows an antimicrobial effect on S. cerevisiae. Therefore, we have investigated the activities of thirteen flavone analogues on S. cerevisiae in our studies. Because flavonoids including flavones have antioxidative effects, we try to carry out the activity studies of flavone analogues in vitro and in vivo. In addition, the relationships between the structures of flavone analogues and their biological activities, such as antimicrobial and antioxidative effects, were elucidated using Comparative Molecular Field Analysis calculations. Of the flavone analogues tested here, 3,2'-dihydroxyflavone showed both good antimicrobial and antioxidative activities.
KeywordsAntimicrobial, flavonoid, Saccharomyces cerevisiae, Caenorhabditis elegans, antioxidative effect