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Molecular and Cellular Microbiology (MCM)  |  Microbial Genomes and Metagenomics

An Overview of the Genetic Variations of the SARS-CoV-2 Genomes Isolated in Southeast Asian Countries

Polly Soo Xi Yap1,*, Tse Siang Tan2, Yoke Fun Chan1, Kok Keng Tee1, Adeeba Kamarulzaman3, Cindy Shuan Ju Teh1,*

1Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia 2Department of Anaesthesiology and Intensive Care, UKM Medical Centre, 56000 Kuala Lumpur, Malaysia 3Department of Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia

Correspondence to:
Cindy Shuan Ju Teh,
E-mail : cindysjteh@um.edu.my
Received: June 6, 2020; Revised: June 17, 2020; Accepted: June 21, 2020

J. Microbiol. Biotechnol. 2020; 30(7): 962-966

Published July 28, 2020 https://doi.org/10.4014/jmb.2006.06009

Copyright © The Korean Society for Microbiology and Biotechnology.

Abstract

Monitoring the mutation dynamics of human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical in understanding its infectivity, virulence and pathogenicity for development of a vaccine. In an “age of mobility,” the pandemic highlights the importance and vulnerability of regionalization and labor market interdependence in Southeast Asia. We intend to characterize the genetic variability of viral populations within the region to provide preliminary information for regional surveillance in the future. By analyzing 142 complete genomes from South East Asian (SEA) countries, we identified three central variants distinguished by nucleotide and amino acid changes.

Keywords

Coronavirus, SARS-CoV-2, genetic variation, COVID-19, mutation, Southeast Asia

Graphical Abstract


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