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Molecular and Cellular Microbiology (MCM)  |  Infection and Immunity

Progress and Challenges in the Development of COVID-19 Vaccines and Current Understanding of SARS-CoV-2- Specific Immune Responses

Kyun-Do Kim† , Insu Hwang† , Keun Bon Ku† , Sumin Lee, Seong-Jun Kim*, and Chonsaeng Kim*

Center for Convergent Research of Emerging Virus Infection, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea

Correspondence to:
Seong-Jun Kim, 
sekim@krict.re.kr
Chonsaeng Kim, 
chonskim@krict.re.kr
Received: June 3, 2020; Revised: June 15, 2020; Accepted: June 15, 2020

J. Microbiol. Biotechnol. 2020; 30(8): 1109-1115

Published August 28, 2020 https://doi.org/10.4014/jmb.2006.06006

Copyright © The Korean Society for Microbiology and Biotechnology.

Abstract

The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is spreading globally, and the WHO has declared this outbreak a pandemic. Vaccines are an effective way to prevent the rapid spread of COVID-19. Furthermore, the immune response against SARS-CoV-2 infection needs to be understood for the development of an efficient and safe vaccine. Here, we review the current understanding of vaccine targets and the status of vaccine development for COVID-19. We also describe host immune responses to highly pathogenic human coronaviruses in terms of innate and adaptive immunities.

Keywords

COVID-19, SARS-CoV-2, Coronavirus, vaccine, immune response

Graphical Abstract


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