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Immune-stimulating Effect of Lactobacillus plantarum Ln1 Isolated from the Traditional Korean Fermented Food, KimchiHye Ji Jang , Hyung-Seok Yu , Na-Kyoung Lee and Hyun-Dong Paik *
Department of Food Science and Biotechnology of Animal Resources, Konkuk University, Seoul 05029, Republic of KoreaReceived: January 22, 2020; Accepted: March 19, 2020
J. Microbiol. Biotechnol.
Published online March 20, 2020
Copyright © The Korean Society for Microbiology and Biotechnology.
AbstractThis study aimed to determine the immune-stimulating effects of heat-killed Lactobacillus plantarum Ln1 (HK-Ln1) through the production of nitric oxide (NO) and pro-inflammatory cytokine achieved by inducing NF-κB and mitogen-activated protein kinase (MAPK)-signaling pathways in macrophages. HK-Ln1 showed higher NO and cytokine production compared to control (non-stimulated lipopolysaccharide); in addition, the expression of inducible nitric oxide synthase (iNOS) was induced through HK-Ln1treatment. The phosphorylation of IκB-α and p65 increased following treatment by HK-Ln1, which implicates IκB-α degradation and the translocation of p65 to nucleus. In addition, the phosphorylation of MAPKs, ERK 1/2, JNK, and p38 was induced following HK-Ln1 treatment.
KeywordsLactobacillus plantarum, probiotics, heat-killed cells, immune-stimulating