Journal of Microbiology and Biotechnology
The Korean Society for Microbiology and Biotechnology publishes the Journal of Microbiology and Biotechnology.

2019 ; Vol.29-12: 2022~2025

AuthorHyeng-Jeong Go, Byung-Joo Park, Hee-Seop Ahn, Eu-Lim Lyoo, Dong-Hwi Kim, Joong-Bok Lee, Seung-Yong Park, Chang-Seon Song, Sang-Won Lee, In-Soo Choi
Place of dutyDepartment of Infectious Diseases, College of Veterinary Medicine, Konkuk University, Seoul 05029, Republic of Korea
TitleIdentification of Hepatitis E Virus in Bovine and Porcine Raw Livers
PublicationInfo J. Microbiol. Biotechnol.2019 ; Vol.29-12
AbstractSeveral animal species including pigs are directly involved in the zoonotic transmission of the hepatitis E virus (HEV) to humans. This study was conducted to detect HEV in bovine and porcine raw livers by nested reverse transcription-polymerase chain reaction. Zoonotic HEV strains were identified in 1.0 and 3.0% of the tested bovine and porcine livers, respectively. HEV-4 was detected in the bovine livers, but both HEV-3 and HEV-4 were identified in the porcine livers. These results indicate that zoonotic transmission of HEV may occur via consumption of raw or undercooked livers of pigs and cattle.
Full-Text
Key_wordHEV-3, HEV-4, pig, cattle, liver
References
  1. Tam AW, Smith MM, Guerra ME, Huang CC, Bradley DW, Fry KE, et al. 1991. Hepatitis E virus (HEV): molecular cloning and sequencing of the full-length viral genome. Virology 185: 120-131.
    CrossRef
  2. Kang S, Myoung J. 2017. Host innate immunity against Hepatitis E virus and viral evasion mechanisms. J. Microbiol. Biotechnol. 27: 1727-1735.
    Pubmed CrossRef
  3. Jilani N, Das BC, Husain SA, Baweja UK, Chattopadhya D, Gupta RK, et al. 2007. Hepatitis E virus infection and fulminant hepatic failure during pregnancy. J. Gastroen. Hepatol. 22: 676-682.
    Pubmed CrossRef
  4. Myoung J, Min KS. 2019. Dose-dependent inhibition of melanoma differentiation-associated gene 5-Mediated activation of type I interferon responses by methyltransferase of Hepatitis E Virus. J. Microbiol. Biotechnol. 29: 1137-1143.
    Pubmed CrossRef
  5. Kang S, Choi C, Choi I, Han KN, Roh SW, Choi J, et al. 2018. Hepatitis E virus methyltransferase inhibits type I interferon induction by targeting RIG-I. J. Microbiol. Biotechnol. 28: 1554-1562.
    Pubmed CrossRef
  6. Tei S, Kitajima N, Takahashi K, Mishiro S. 2003. Zoonotic transmission of hepatitis E virus from deer to human beings. Lancet 362: 371-373.
    CrossRef
  7. Yazaki Y, Mizuo H, Takahashi M, Nishizawa T, Sasaki N, Gotanda Y, et al. 2003. Sporadic acute or fulminant hepatitis E in Hokkaido, Japan, may be food-borne, as suggested by the presence of hepatitis E virus in pig liver as food. J. Gen. Virol. 84: 2351-2357.
    Pubmed CrossRef
  8. Takahashi K, Kitajima N, Abe N, Mishiro S. 2004. Complete or near-complete nucleotide sequences of hepatitis E virus genome recovered from a wild boar, a deer, and four patients who ate the deer. Virology 330: 501-505.
    Pubmed CrossRef
  9. Lee GH, Tan BH, Teo ECY, Lim SG, Dan YY, Wee A, et al. 2016. Chronic infection with camelid hepatitis E virus in a liver transplant recipient who regularly consumes camel meat and milk. Gastroenterology 150: 355-+.
    Pubmed CrossRef
  10. Jung K, Kang B, Song DS, Chae C. 2007. Prevalence and genotyping of hepatitis E virus in swine population in Korea between 1995 and 2004: A retrospective study. Vet. J. 173: 683-687.
    Pubmed CrossRef
  11. Lee SH, Kang SC, Kim DY, Bae JH, Kim JH. 2007. Detection of swine hepatitis E virus in the porcine hepatic lesion in Jeju Island. J. Vet. Sci. 8: 51-55.
    Pubmed CrossRef Pubmed Central
  12. Forgach P, Nowotny N, Erdelyi K, Boncz A, Zentai J, Szucs G, et al. 2010. Detection of Hepatitis E virus in samples of animal origin collected in Hungary. Vet. Microbiol. 143: 106-116.
    Pubmed CrossRef
  13. Prpic J, Cerni S, Skoric D, Keros T, Brnic D, Cvetnic Z, et al. 2015. Distribution and molecular characterization of hepatitis E virus in domestic animals and wildlife in Croatia. Food Environ. Virol. 7: 195-205.
    Pubmed CrossRef
  14. Kim YH, Park BJ, Ahn HS, Han SH, Go HJ, Kim DH, et al. 2018. Detection of hepatitis E virus genotypes 3 and 4 in pig farms in Korea. J. Vet. Sci. 19: 309-312.
    Pubmed CrossRef Pubmed Central
  15. Ahn JM, Kang SG, Lee DY, Shin SJ, Yoo HS. 2005. Identification of novel human hepatitis E virus (HEV) isolates and determination of the seroprevalence of HEV in Korea. J. Clin. Microbiol. 43: 3042-3048.
    Pubmed CrossRef Pubmed Central
  16. Jeong SH, Park BJ, Kim YH, Choi YS, Ahn HS, Han SH, et al. 2017. Isolation of hepatitis E virus genotype 4 from patients with acute cryptogenic hepatitis in Korea. J. Clin. Virol. 89: 10-13.
    Pubmed CrossRef
  17. Huang F, Li YL, Yu WH, Jing SR, Wang J, Long FY, et al. 2016. Excretion of infectious hepatitis E virus into milk in cows imposes high risks of zoonosis. Hepatology 64: 350-359.
    Pubmed CrossRef
  18. Yan BY, Zhang L, Gong LF, Lv JJ, Feng Y, Liu JY, et al. 2016. Hepatitis E virus in Yellow Cattle, Shandong, Eastern China. Emerg. Infect. Dis. 22: 2211-2212.
    Pubmed CrossRef Pubmed Central
  19. Takahashi H, Tanaka T, Jirintai S, Nagashima S, Takahashi M, Nishizawa T, et al. 2012. A549 and PLC/PRF/5 cells can support the efficient propagation of swine and wild boar hepatitis E virus (HEV) strains: demonstration of HEV infectivity of porcine liver sold as food. Arch. Virol. 157: 235-246.
    Pubmed CrossRef
  20. Meng XJ, Purcell RH, Halbur PG, Lehman JR, Webb DM, Tsareva TS, et al. 1997. A novel virus in swine is closely related to the human hepatitis E virus. Proc. Natl. Acad. Sci. USA 94: 9860-9865.
    Pubmed CrossRef Pubmed Central
  21. Wang YC, Zhang HY, Li Z, Gu WJ, Lan HY, Hao W, et al. 2001. Detection of sporadic cases of hepatitis e virus (HEV) infection in china using immunoassays based on recombinant open reading frame 2 and 3 polypeptides from HEV genotype 4. J. Clin. Microbiol. 39: 4370-4379.
    Pubmed CrossRef Pubmed Central
  22. Bouwknegt M, Lodder-Verschoor F, Van Der Poel WHM, Rutjes SA, De Roda Husman AM. 2007. Hepatitis E virus RNA in commercial porcine livers in the Netherlands. J. Food Protect. 70: 2889-2895.
    Pubmed CrossRef
  23. Feagins AR, Opriessnig T, Guenette DK, Halbur PG, Meng XJ. 2007. Detection and characterization of infectious Hepatitis E virus from commercial pig livers sold in local grocery stores in the USA. J. Gen. Virol. 88: 912-917.
    Pubmed CrossRef
  24. Li TC, Chijiwa K, Sera N, Ishibashi T, Etoh Y, Shinohara Y, et al. 2005. Hepatitis E virus transmission from wild boar meat. Emerg. Infect. Dis. 11: 1958-1960.
    Pubmed CrossRef Pubmed Central
  25. Wenzel JJ, Preiss J, Schemmerer M, Huber B, Plentz A, Jilg W. 2011. Detection of hepatitis E virus (HEV) from porcine livers in Southeastern Germany and high sequence homology to human HEV isolates. J. Clin. Virol. 52: 50-54.
    Pubmed CrossRef
  26. Reuter G, Fodor D, Forgach P, Katai A, Szucs G. 2009. Characterization and zoonotic potential of endemic hepatitis E virus (HEV) strains in humans and animals in Hungary. J. Clin. Virol. 44: 277-281.
    Pubmed CrossRef
  27. Hu GD, Ma X. 2010. Detection and sequences analysis of bovine hepatitis E virus RNA in Xinjiang Autonomous Region. Bing Du Xue Bao 26: 27-32.



Copyright © 2009 by the Korean Society for Microbiology and Biotechnology.
All right reserved. Mail to jmb@jmb.or.kr
Online ISSN: 1738-8872    Print ISSN: 1017-7825    Powered by INFOrang Co., Ltd