2019 ; Vol.29-11: 1852~1859
|Author||Sojung Bae, Jeong Yoon Lee, Jinjong Myoung|
|Place of duty||Korea Zoonosis Research Institute and Genetic Engineering Research Institute, Jeonbuk National University, Jeonju 54531, Republic of Korea|
|Title||Chikungunya Virus-Encoded nsP2, E2 and E1 Strongly Antagonize the Interferon-β Signaling Pathway|
J. Microbiol. Biotechnol.2019 ;
|Abstract||Chikungunya virus (CHIKV) is a single-stranded positive-sense RNA virus, belonging to the
genus Alphavirus of the Togaviridae family. It causes multiple symptoms, including headache,
fever, severe joint and muscle pain, and arthralgia. Since CHIKV was first isolated in Tanzania
in 1952, there have been multiple outbreaks of chikungunya fever. However, its pathogenesis
and mechanisms of viral immune evasion have been poorly understood. In addition, the exact
roles of individual CHIKV genes on the host innate immune response remain largely
unknown. To investigate if CHIKV-encoded genes modulate the type I interferon (IFN)
response, each and every CHIKV gene was screened for its effects on the induction of the IFN-
β promoter. Here we report that CHIKV nsP2, E2 and E1 strongly suppressed activation of the
IFN-β promoter induced by the MDA5/RIG-I receptor signaling pathway, suggesting that
nsP2, E2, and E1 are the major antagonists against induction of IFN-β. Delineation of
underlying mechanisms of CHIKV-mediated inhibition of the IFN-β pathway may help
develop virus-specific therapeutics and vaccines.|
|Key_word||Chikungunya virus, interferon, antagonist|
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