2019 ; Vol.29-9: 1369~1374
|Author||Sang-Kap Han, Dong Hyun Kim|
|Place of duty||Neurobiota Research Center, Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea|
|Title||Lactobacillus mucosae and Bifidobacterium longum Synergistically Alleviate Immobilization Stress-Induced Anxiety/Depression in Mice by Suppressing Gut Dysbiosis|
J. Microbiol. Biotechnol.2019 ;
|Abstract||We isolated Lactobacillus mucosae NK41 and Bifidobacterium longum NK46 from human feces,
which induced BDNF expression in corticosterone-stimulated SH-SY5Y cells, and examined
their anti-depressive effects in mice. NK41, NK46, and their (1:1) mixture significantly
mitigated immobilization stress (IS)-induced anxiety-like/depressive behaviors, hippocampal
NF-κB activation, BDNF expression, Iba1+ cell population, and blood corticosterone, TNF-α, IL-
6, and lipopolysaccharide levels. Furthermore, they inhibited colitis marker NF-κB activation,
and TNF-α expression in mice with IS-induced anxiety/depression. They additionally
suppressed gut Proteobacteria and Bacteroidetes populations and bacterial lipopolysaccharide
production. These findings suggest that NK41 and NK46 may alleviate anxiety/depression
and colitis by suppressing gut dysbiosis.|
|Key_word||Bifidobacterium longum, Lactobacillus mucosae, depression, anxiety, gut microbiota|
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