2019 ; Vol.29-11: 1745~1748
|Author||Anna Jong, Cheng Chung Yong, Oh Sejong|
|Place of duty||Division of Animal Science, Chonnam National University, Gwangju 61186, Republic of Korea|
|Title||Bioconversion of Gamma-Aminobutyric Acid from Monosodium Glutamate by Lactobacillus brevis Bmb5|
J. Microbiol. Biotechnol.2019 ;
|Abstract||Gamma-aminobutyric acid (GABA) plays important roles in host physiology. However, the
effects of GABA are greatly restricted due to its low bioavailability in the human body. Here, a
high acid-tolerance GABA-producing strain, Lactobacillus brevis Bmb5, was isolated from
kimchi. Bmb5 converted glutamate to GABA (7.23 ± 0.68 μg/μl) at a rate of 72.3%. The
expression of gadB gene, encoding the enzyme involved in the decarboxylation of glutamate to
GABA, was decreased upon incubation. Our findings indicate GABA production in Bmb5 is
not directly correlated with gadB gene expression, providing new insight into the mechanisms
underlying GABA production in Lactobacillus.|
|Key_word||Monosodium glutamate, Lactobacillus, GABA, gene expression, glutamic acid decarboxylase|
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