2020 ; Vol.30-1: 11~20
|Author||Rubin Thapa Magar, Jae Kyung Sohng|
|Place of duty||Department of Life Science and Biochemical Engineering, Sun Moon University, Republic of Korea|
|Title||A Review on Structure, Modifications and Structure-Activity Relation of Quercetin and Its Derivatives|
J. Microbiol. Biotechnol.2020 ;
|Abstract||Quercetin and its derivatives are important metabolites that belong to the flavonol class of
flavonoids. Quercetin and some of the conjugates have been approved by the FDA for human
use. They are widely distributed among plants and have various biological activities, such as
being anticancer, antiviral, and antioxidant. Hence, the biosynthesis of novel derivatives is an
important field of research. Glycosylation and methylation are two important modification
strategies that have long been used and have resulted in many novel metabolites that are not
present in natural sources. A strategy for modifying quercetin in E. coli by means of
glycosylation, for example, involves overexpressing respective glycosyltransferases (GTs) in
the host and metabolic engineering for increasing nucleoside diphosphate sugar (NDP sugar).
Still others have used microorganisms other than E. coli, such as Streptomyces sp., for the
biotransformation process. The overall study of the structural activity relationship has
revealed that modification of some residues in quercetin decreased one activity but increased
others. This review summarizes all of the information mentioned above.|
|Key_word||Quercetin, glycosylation, methylation, biotransformation|
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