2019 ; Vol.29-9: 1335~1340
|Author||Seon-Kyun Kim, Robin B. Guevarra, You-Tae Kim, Joongi Kwon, Hyeri Kim, Jae Hyoung Cho, Hyeun Bum Kim, Ju-Hoon Lee|
|Place of duty||Department of Food Science and Biotechnology, Kyung Hee University, Yongin 17104, Republic of Korea|
|Title||Role of Probiotics in Human Gut Microbiome-Associated Diseases|
J. Microbiol. Biotechnol.2019 ;
|Abstract||Probiotics, including bacteria and yeast, are live microorganisms that have demonstrated
beneficial effects on human health. Recently, probiotic bacteria are constantly being studied
and their applications are also being considered in promising adjuvant treatments for various
intestinal diseases. Clinical trials and in vivo experiments have extended our current
understanding of the important roles that probiotics play in human gut microbiomeassociated
diseases. It has been documented through many clinical trials that probiotics could
shape the intestinal microbiota leading to potential control of multiple bowel diseases and
promotion of overall wellness. In this review, we focused on the relationship between
probiotics and the human gut microbiota and its roles in gut microbiome-associated diseases.
Here, we also discuss future directions and research areas that need further elucidation in
order to better understand the roles of probiotics in the treatment of intestinal diseases.|
|Key_word||Human gut microbiota, intestinal disease, probiotics|
de Simone C. 2018. The unregulated probiotic market. Clin. Gastroenterol. H. 17: 809-817
Choi S, Hwang Y-J, Shin M-J, Yi H. 2017. Difference in the gut microbiome between Ovariectomy-induced obesity and diet-induced obesity. J. Microbiol. Biotechnol. 27: 2228-2236.
Qin J, Li R, Raes J, Arumugam M, Burgdorf KS, Manichanh C, et al. 2010. A human gut microbial gene catalogue established by metagenomic sequencing. Nature 464: 59-65.
Wang W, Xing W, Wei S, Gao Q, Wei X, Shi L, et al. 2018. Semi-rational screening of the probiotics from the fecal flora of healthy adults against DSS-induced colitis mice by enhancing anti-inflammatory activity and modulating the gut microbiota. J. Microbiol. Biotechnol. [Epub ahead of print]
Sanders ME, Heimbach JT, Pot B, Tancredi DJ, LenoirWijnkoop I, Lähteenmäki-Uutela A, et al. 2 011. H ealth claims substantiation for probiotic and prebiotic products. Gut Microbes 2: 127-133.
Lorea Baroja M, Kirjavainen P, Hekmat S, Reid G. 2007. Anti-inflammatory effects of probiotic yogurt in inflammatory bowel disease patients. Clin. Exp. Immunol. 149: 470-479.
Cremonini F, Di Caro S, Nista EC, Bartolozzi F, Capelli G, Gasbarrini G, et al. 2002. Meta-analysis: the effect of probiotic administration on antibiotic-associated diarrhoea. Aliment. Pharmacol. Ther. 16: 1461-1467.
Bae J-Y, Kim JI, Park S, Yoo K, Kim I-H, Joo W, et al. 2018. Effects of Lactobacillus plantarum and Leuconostoc mesenteroides Probiotics on Human Seasonal and Avian Influenza Viruses. J. Microbiol. Biotechnol. 28: 893-901.
Clemente JC, Ursell LK, Parfrey LW, Knight R. 2012. The impact of the gut microbiota on human health: an integrative view. Cell 148: 1258-1270.
Ley RE, Peterson DA, Gordon JI. 2006. Ecological and evolutionary forces shaping microbial diversity in the human intestine. Cell 124: 837-848.
Flint H J, S cott K P, D uncan SH, Louis P, F orano E. 2 012. Microbial degradation of complex carbohydrates in the gut. Gut Microbes 3: 289-306.
Apajalahti J. 2005. Comparative gut microflora, metabolic challenges, and potential opportunities. J. Appl. Poultry Res.14: 444-453.
Wen H, Yin X, Yuan Z, Wang X, Su S. 2018. Comparative Analysis of Gut Microbial Communities in Children under 5 Years Old with Diarrhea. J. Microbiol. Biotechnol. 28: 652-662.
Marteau P, Seksik P, Jian R. 2002. Probiotics and intestinal health effects: a clinical perspective. Br. J. Nutr. 88: S51-S57.
Hilty M, Burke C, Pedro H, Cardenas P, Bush A, Bossley C, et al. 2010. Disordered microbial communities in asthmatic airways. PLoS One 5(1): e8578.
Carding S, Verbeke K, Vipond DT, Corfe BM, Owen LJ. 2015. Dysbiosis of the gut microbiota in disease. Microb. Ecol. Health Dis. 26: 26191.
Ouwehand A, Kirjavainen P, Grönlund M-M, Isolauri E, Salminen S. 1999. Adhesion of probiotic micro-organisms to intestinal mucus. Int. Dairy J. 9: 623-630.
Blaabjerg S, Artzi DM, Aabenhus R. 2017. Probiotics for the Prevention of Antibiotic-Associated Diarrhea in OutpatientsA Systematic Review and Meta-Analysis. Antibiotics. 6(4).pii: E21.
Conway S, Hart A, Clark A, Harvey I. 2007. Does eating yogurt prevent antibiotic-associated diarrhoea?: A placebocontrolled randomised controlled trial in general practice. Br. J. Gen. Pract. 57: 953-959.
Vanderhoof JA, Whitney DB, Antonson DL, Hanner TL, Lupo JV, Young RJ. 1999. Lactobacillus GG in the prevention of antibiotic-associated diarrhea in children. J. Pediatr. 135:564-568.
Bjarnason I, Sission G, Hayee B. 2019. A randomised, double-blind, placebo-controlled trial of a multi-strain probiotic in patients with asymptomatic ulcerative colitis and Crohn’s disease. Inflammopharmacology 27: 465-473.
Shadnoush M, Hosseini RS, Khalilnezhad A, Navai L, Goudarzi H, Vaezjalali M. 2015. Effects of Probiotics on Gut Microbiota in Patients with Inflammatory Bowel Disease: A Double-blind, Placebo-controlled Clinical Trial. Korean J. Gastroenterol. 65: 215-221.
Yang J, Yu J. 2018. The association of diet, gut microbiota and colorectal cancer: what we eat may imply what we get. Protein Cell 9: 474-487.
Furrie E, Macfarlane S, Kennedy A, Cummings J, Walsh S, O’Neil D, et al. 2005. Synbiotic therapy (Bifidobacterium longum/Synergy 1) initiates resolution of inflammation in patients with active ulcerative colitis: a randomised controlled pilot trial. Gut 54: 242-249.
Baumgart DC, Carding SR. 2007. Inflammatory bowel disease: cause and immunobiology. Lancet 369: 1627-1640.
Cowan DC, Cowan JO, Palmay R, Williamson A, Taylor DR. 2010. Effects of steroid therapy on inflammatory cell subtypes in asthma. Thorax 65: 384-390.
Fedorak RN, Feagan BG, Hotte N, Leddin D, Dieleman LA, Petrunia DM, et al. 2015. The probiotic VSL#3 has antiinflammatory effects and could reduce endoscopic recurrence after surgery for Crohn’s disease. Clin. Gastroenterol. Hepatol. 13: 928-935.
Center MM, Jemal A, Smith RA, Ward E. 2009. Worldwide variations in colorectal cancer. CA Cancer J. Clin. 59: 366-378.
Triantafillidis JK, Nasioulas G, Kosmidis PA. 2009. Colorectal cancer and inflammatory bowel disease: epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies. Anticancer Res. 29: 2727-2737.
Liong M-T. 2008. Roles of probiotics and prebiotics in colon cancer prevention: postulated mechanisms and in-vivo evidence. Int. J. Mol. Sci. 9: 854-863.
Krebs B. 2016. Prebiotic and Synbiotic treatment before colorectal surgery-randomised double blind trial. Coll. Antropol. 40: 35-40.
Boyle, R. J., Robins-Browne, R. M., & Tang, M. L. 2006. Probiotic use in clinical practice: what are the risks?. Am. J. Clin. Nutr. 83: 1256-1264.
Beniwal RS, Arena VC, Thomas L, Narla S, Imperiale TF, Chaudhry RA, et al. 2003. A randomized trial of yogurt for prevention of antibiotic-associated diarrhea. Dig. Dis. Sci. 48:2077-2082.
Yang Y, Xia Y, Chen H, Hong L, Feng J, Yang J, et al. 2016. The effect of perioperative probiotics treatment for colorectal cancer: short-term outcomes of a randomized controlled trial. Oncotarget 7: 8432-8440.