2019 ; Vol.29-8: 1248~1254
|Author||Minju Jeong, Jae Hwan Kim, Hee Yang, Shin Dal Kang, Seongbong Song, Deukbuhm Lee, Ji Su Lee, Jung Han Yoon Park, Sanguine Byun, Ki Won Lee|
|Place of duty||Department of Agricultural Biotechnology, Seoul National University, Seoul 08826, Republic of Korea|
|Title||Heat-Killed Lactobacillus plantarum KCTC 13314BP Enhances Phagocytic Activity and Immunomodulatory Effects Via Activation of MAPK and STAT3 Pathways|
J. Microbiol. Biotechnol.2019 ;
|Abstract||Identification of novel probiotic strains is of great interest in the field of functional foods.
Specific strains of heat-killed bacteria have been reported to exert immunomodulatory effects.
Herein, we investigated the immune-stimulatory function of heat-killed Lactobacillus plantarum
KCTC 13314BP (LBP). Treatment with LBP significantly increased the production of TNF-α
and IL-6 by macrophages. More importantly, LBP was able to enhance the phagocytic activity
of macrophages against bacterial particles. Activation of p38, JNK, ERK, NF-κB, and STAT3
was involved in the immunomodulatory function of LBP. LBP treatment significantly
increased production of TNF-α by bone marrow-derived macrophages and splenocytes,
further confirming the immunostimulatory effect of LBP in primary immune cells.
Interestingly, the immunomodulatory effects of LBP were much stronger than those of
Lactobacillus rhamnosus GG, a well-known probiotic strain. These results indicate that LBP can
be a promising immune-enhancing functional food agent.|
|Key_word||Lactobacillus plantarum, immunomodulatory effect, phagocytosis, macrophages|
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