2019 ; Vol.29-9: 1361~1368
|Author||Ji Eun Kim, Chaiwat Monmai, Weerawan Rod-in, A-yeong Jang, Sang-Guan You, Sang-min Lee, Woo Jung Park|
|Place of duty||Department of Wellness-Bio Industry, Gangneung-Wonju National University, Gangneung 25457, Republic of Korea|
|Title||Immune Enhancement Effects of Codium fragile Anionic Macromolecules Combined with Red Ginseng Extract in Immune-Suppressed Mice|
J. Microbiol. Biotechnol.2019 ;
|Abstract||Codium fragile is an edible seaweed in Asian countries that has been used as a thrombolytic,
anticoagulant, antioxidant, anti-inflammatory, and immune-stimulatory agent. Ginseng has
also been known to maintain immune homeostasis and to regulate the immune system via
enhancing resistance to diseases and microorganisms. In this study, anionic macromolecules
extracted from C. fragile (CFAM) were orally administered with red ginseng extract (100 mg/kg
body weight) to cyclophosphamide-induced immunosuppressed male BALB/c mice to
investigate the immune-enhancing cooperative effect of Codium fragile and red ginseng. Our
results showed that supplementing CFAM with red ginseng extract significantly increased
spleen index, T- and B-cell proliferation, NK cell activity, and splenic lymphocyte immuneassociated
gene expression compared to those with red ginseng alone, even though a high
concentration of CFAM with red ginseng decreased immune biomarkers. These results
suggest that CFAM can be used as a co-stimulant to enhance health and immunity in
|Key_word||Anionic macromolecules, Codium fragile, red ginseng extract, cyclophosphamide, immune-suppressed mice|
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