2019 ; Vol.29-11: 1841~1851
|Author||H N Fernando, U R Kumarasinghe, C P Gunasekara, S K Wijekoon, A K Ekanayaka, S P Rajapaksha, S N Fernando, P M Jayaweera|
|Place of duty||Department of Chemistry, Faculty of Applied Sciences, University of Sri Jayewardenepura 10250, Sri Lanka|
|Title||Synthesis, Characterization and Antimicrobial Activity of Garcinol Capped Silver Nanoparticles|
J. Microbiol. Biotechnol.2019 ;
|Abstract||Garcinol, a well-known medicinal phytochemical, was extracted and isolated from the dried
fruit rinds of Garcinia quaesita Pierre. In this study, garcinol has successfully used to reduce
silver ions to silver in order to synthesize garcinol-capped silver nanoparticles (G-AgNPs).
The formation and the structure of G-AgNPs were confirmed by UV-visible spectroscopy,
transmission electron microscopy and Fourier transform infrared (FTIR) spectroscopy.
The antimicrobial activity of garcinol and G-AgNPs were investigated by well diffusion
assays, broth micro-dilution assays and time-kill kinetics studies against five microbial
species, including Staphylococcus aureus (ATCC 25923), Pseudomonas aeruginosa (ATCC 27853),
Escherichia coli (ATCC 25922), Candida albicans (ATCC 10231) and clinically isolated
methicillin-resistant Staphylococcus aureus (MRSA). The formation of G-AgNPs is a promising
novel approach to enhancing the biological activeness of silver nanoparticles, and to increase
the water solubility of garcinol which creates a broad range of therapeutic applications.|
|Key_word||Garcinol, silver nanoparticles, garcinol capped silver nanoparticles, antimicrobial activity, time-kill kinetic studies|
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