Journal of Microbiology and Biotechnology
The Korean Society for Microbiology and Biotechnology publishes the Journal of Microbiology and Biotechnology.

2019 ; Vol.29-8: 1184~1192

AuthorChang Woo Han, Mi Suk Jeong, Se Bok Jang
Place of dutyDepartment of Molecular Biology, College of Natural Sciences, Pusan National University, Busan 46241, Republic of Korea
TitleStructure and Function of the Influenza A Virus Non-Structural Protein 1
PublicationInfo J. Microbiol. Biotechnol.2019 ; Vol.29-8
AbstractThe influenza A virus is a highly infectious respiratory pathogen that sickens many people with respiratory disease annually. To prevent outbreaks of this viral infection, an understanding of the characteristics of virus-host interaction and development of an anti-viral agent is urgently needed. The influenza A virus can infect mammalian species including humans, pigs, horses and seals. Furthermore, this virus can switch hosts and form a novel lineage. This so-called zoonotic infection provides an opportunity for virus adaptation to the new host and leads to pandemics. Most influenza A viruses express proteins that antagonize the antiviral defense of the host cell. The non-structural protein 1 (NS1) of the influenza A virus is the most important viral regulatory factor controlling cellular processes to modulate host cell gene expression and double-stranded RNA (dsRNA)-mediated antiviral response. This review focuses on the influenza A virus NS1 protein and outlines current issues including the life cycle of the influenza A virus, structural characterization of the influenza A virus NS1, interaction between NS1 and host immune response factor, and design of inhibitors resistant to the influenza A virus.
Full-Text
Key_wordInfluenza A virus, NS1, virus-host interaction, antiviral defense, inhibitor
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