2019 ; Vol.29-8: 1184~1192
|Author||Chang Woo Han, Mi Suk Jeong, Se Bok Jang|
|Place of duty||Department of Molecular Biology, College of Natural Sciences, Pusan National University, Busan 46241, Republic of Korea|
|Title||Structure and Function of the Influenza A Virus Non-Structural Protein 1|
J. Microbiol. Biotechnol.2019 ;
|Abstract||The influenza A virus is a highly infectious respiratory pathogen that sickens many people
with respiratory disease annually. To prevent outbreaks of this viral infection, an
understanding of the characteristics of virus-host interaction and development of an anti-viral
agent is urgently needed. The influenza A virus can infect mammalian species including
humans, pigs, horses and seals. Furthermore, this virus can switch hosts and form a novel
lineage. This so-called zoonotic infection provides an opportunity for virus adaptation to the
new host and leads to pandemics. Most influenza A viruses express proteins that antagonize
the antiviral defense of the host cell. The non-structural protein 1 (NS1) of the influenza A
virus is the most important viral regulatory factor controlling cellular processes to modulate
host cell gene expression and double-stranded RNA (dsRNA)-mediated antiviral response.
This review focuses on the influenza A virus NS1 protein and outlines current issues including
the life cycle of the influenza A virus, structural characterization of the influenza A virus NS1,
interaction between NS1 and host immune response factor, and design of inhibitors resistant
to the influenza A virus.|
|Key_word||Influenza A virus, NS1, virus-host interaction, antiviral defense, inhibitor|
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