2019 ; Vol.29-5: 739~748
|Author||Ha Gyoon Na, Yuna Park , Min-Ah Kim, Jin Woo Lee, Gyeongseop So, Sung Hyeok Kim, Ki-Hyo Jang, Mi-Ja Kim, Seung Namkoong , Hyun Jung Koo, Sung Ryul Lee , Eun-Hwa Sohn|
|Place of duty||Department of Food & Nutrition, Kangwon National University, Republic of Korea|
|Title||Secondary Fermented Extract of Chaga-Cheonggukjang Attenuates the Effects of Obesity and Suppresses Inflammatory Response in the Liver and Spleen of High-Fat Diet-Induced Obese Mice|
J. Microbiol. Biotechnol.2019 ;
|Abstract||Cheonggukjang and chaga mushrooms have numerous health benefits, and have been used in
alternative medicine. Therefore, a powder mixture of 98: Cheonggukjang and 2: Chaga extracts
was fermented with Lactobacillus acidophilus KCTC3925 (FCC) and its anti-obesity effects in
high-fat diet (HFD)-induced obese mice were determined. Five-week-old male ICR mice were
fed a normal diet or HFD in the presence or absence of 3% and 5% FCC by weight (n = 10 per
group). After 12 weeks, the mice were sacrificed, and the serum and tissue samples were
collected for analysis. Body weight and epididymal fat pad weight were significantly lowered
in the 3% and 5% FCC groups compared with those in the HFD control group (p < 0.01). FCC
supplementation suppressed serum triglyceride and increased serum HDL-C levels (p < 0.01).
Serum GOT, GPT, and leptin levels, hepatic COX-2 mRNA expression, and splenic COX-2 and
IL-4 mRNA expression were significantly higher in the HFD groups than in the control group
(p > 0.05); however, except for splenic IL-4 levels, the increases were significantly attenuated
by FCC supplementation. Expression of ICAM-1, an aortic inflammatory marker, was
significantly increased in the HFD group; this effect was suppressed in the 3% FCC group (p <
0.01) but not in the 5% FCC group. FCC suppressed the body weight and epididymal fat pad
weight gain, as well as inflammatory responses in the liver and spleen of HFD-fed mice. Thus,
FCC supplementation will be beneficial for the treatment of obesity-related effects.|
|Key_word||Cheonggukjang, chaga mushroom, Lactobacillus acidophilus KCTC 3925, high-fat diet, anti-obesity, inflammatory molecules|
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