Journal of Microbiology and Biotechnology
The Korean Society for Microbiology and Biotechnology publishes the Journal of Microbiology and Biotechnology.

2019 ; Vol.29-11: 1739~1744

AuthorMijoo Choi, Yunjung Lee, Na-Kyoung Lee, Chun Ho Bae, Dae Chul Park, Hyun-Dong Paik, Eunju Park
Place of dutyDepartment of Food and Nutrition, Kyungnam University, Changwon 51767, Republic of Korea
TitleImmunomodulatory Effects by Bifidobacterium longum KACC 91563 in Mouse Splenocytes and Macrophages
PublicationInfo J. Microbiol. Biotechnol.2019 ; Vol.29-11
AbstractThe present study evaluates the immunomodulatory effect of Bifidobacterium longum KACC 91563 in murine primary splenocytes and macrophages. B. longum KACC 91563 regulated Tand B-cell proliferation and inhibited the Th1 (IL-2, IFN-γ)/Th2 (IL-4, IL-10) cytokine imbalance and immune cytokine production. Moreover, immunoglobulin E (IgE) levels were significantly lower after treatment with B. longum KACC 91563. These findings suggest that B. longum KACC 91563 could modulate the systemic immune system toward both IgE production and regulation of the Th1/Th2 balance.
Full-Text
Key_wordBifidobacterium longum KACC 91563, cytokine, immunomodulatory effect, Th1/Th2 balance
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