2019 ; Vol.29-11: 1739~1744
|Author||Mijoo Choi, Yunjung Lee, Na-Kyoung Lee, Chun Ho Bae, Dae Chul Park, Hyun-Dong Paik, Eunju Park|
|Place of duty||Department of Food and Nutrition, Kyungnam University, Changwon 51767, Republic of Korea|
|Title||Immunomodulatory Effects by Bifidobacterium longum KACC 91563 in Mouse Splenocytes and Macrophages|
J. Microbiol. Biotechnol.2019 ;
|Abstract||The present study evaluates the immunomodulatory effect of Bifidobacterium longum KACC
91563 in murine primary splenocytes and macrophages. B. longum KACC 91563 regulated Tand
B-cell proliferation and inhibited the Th1 (IL-2, IFN-γ)/Th2 (IL-4, IL-10) cytokine
imbalance and immune cytokine production. Moreover, immunoglobulin E (IgE) levels were
significantly lower after treatment with B. longum KACC 91563. These findings suggest that
B. longum KACC 91563 could modulate the systemic immune system toward both IgE
production and regulation of the Th1/Th2 balance.|
|Key_word||Bifidobacterium longum KACC 91563, cytokine, immunomodulatory effect, Th1/Th2 balance|
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