2019 ; Vol.29-1: 21~29
|Author||Ji Hoon Ha, A Rang Kim, Keon-Soo Lee, Song Hua Xuan, Hee Cheol Kang, Dong Hwan Lee, Mi Yeon Cha, Hye Jin Kim, Mi An, Soo Nam Park|
|Place of duty||Seoul National University of Science and Technology, Seoul 01811, Republic of Korea|
|Title||Anti-Aging Activity of Lavandula angustifolia Extract Fermented with Pediococcus pentosaceus DK1 Isolated from Diospyros kaki Fruit in UVB-Irradiated Human Skin Fibroblasts and Analysis of Principal Components|
J. Microbiol. Biotechnol.2019 ;
|Abstract||The effects of Lavandula angustifolia extracts fermented with Pediococcus pentosaceus DK1 on
UVB-mediated MMP-1 expression and collagen decrease in human skin fibroblasts
Lavandula angustifolia extract fermented with Pediococcus pentosaceus DK1 were determined on
UVB-mediated MMP-1 expression and collagen decrease in human skin fibroblasts and the
conversion of its components. Fermentation was performed at varying L. angustifolia extract
and MRS medium concentrations, and optimal fermentation conditions were selected.
L. angustifolia extracts showed decreased cytotoxicity after fermentation in the fibroblasts.
UVB-irradiated fibroblasts treated with fermented L. angustifolia extract showed MMP-1
expression 8.2-14.0% lower than that in UVB-irradiated fibroblasts treated with non-fermented
extract. This was observed even at fermented extract concentrations lower than those of nonfermented
extracts. Fibroblasts treated with fermented L. angustifolia extract showed 20% less
reduction in collagen production upon UVB irradiation than those treated with non-fermented
extracts. UVB-irradiated fibroblasts treated with fermented L. angustifolia extracts showed 50%
higher inhibition of ROS generation than those treated with non-fermented extract. Luteolin
and apigenin glycosides of L. angustifolia were converted during fermentation, and identified
using RP-HPLC and LC/ESI-MS. Therefore, the effects of L. angustifolia extract were increased
through fermentation by P. pentosaceus on MMP-1 expression and collagen decrease in UVBirradiated
human skin fibroblasts|
|Key_word||Pediococcus pentosaceus DK1, fermentation, UVB, matrix metalloproteinase-1, procollagen|
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