Journal of Microbiology and Biotechnology
The Korean Society for Microbiology and Biotechnology publishes the Journal of Microbiology and Biotechnology.

2019 ; Vol.29-3: 473~481

AuthorLijun Wang, Baihua Zhou, Xue Zhou, Yang Wang, Hongwei Wang, Shengying Jia, Zhipeng Zhang, Chao Chu, Jianjun Mu
Place of dutyDepartment of Cardiology, Affiliated Zhongshan Hospital, Dalian University, Dalian 116001, China,Department of Cardiology, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Chin
TitleCombined Lowering Effects of Rosuvastatin and L. acidophilus on Cholesterol Levels in Rat
PublicationInfo J. Microbiol. Biotechnol.2019 ; Vol.29-3
AbstractStatins are a class of lipid-lowering drugs commonly used in the prevention of cardiovascular diseases. However, statin therapy presents many limitations, which have led to an increased interest in non-drug therapies, such as probiotics, to improve blood cholesterol levels. Indeed, probiotic strains such as Lactobacillus acidophilus have been found to improve blood lipid profiles, especially in reducing total cholesterol and LDL-C levels. In this study, we established a high-cholesterol rat model and studied the effect of Lactobacillus acidophilus administration alone or in conjunction with rosuvastatin. We were able to show that indeed Lactobacillus exerts a cholesterol-lowering effect. Additionally, we observed that when administered together, rosuvastin and Lactobacillus exert a combined cholesterol-lowering effect. Altogether, our data advocate for the possibility of establishing probiotics as non-drug supplements for the treatment of hypercholesterolemia.
Full-Text
Key_wordLactobacillus acidophilus, rosuvastatin, cholesterol, hypercholesterolemia, cardiovascular disease
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