Journal of Microbiology and Biotechnology
The Korean Society for Microbiology and Biotechnology publishes the Journal of Microbiology and Biotechnology.

2018 ; Vol.28-8: 1391~1400

AuthorYun-A Park, Sung Ryul Lee, Jin Woo Lee, Hyun Jung Koo, Seon-A Jang, Seung-Won Yun, Hyun Ju Kim, Jeong Suk Woo, Myung Rye Park, Se Chan Kang, Youn Kyu Kim, Eun-Hwa Sohn
Place of dutyDepartment of Herbal Medicine Resource, Kangwon National University, Samcheok 25949, Republic of Korea
TitleSuppressive Effect of Fermented Angelica tenuissima Root Extract against Photoaging: Possible Involvement of Hemeoxygenase-1
PublicationInfo J. Microbiol. Biotechnol.2018 ; Vol.28-8
AbstractAngelica tenuissima root has historically been used as a traditional medicine in Korea. Previous studies have identified the anti-melanogenic effects of the extract of A. tenuissima root fermented by Aspergillus oryzae (FAT). This study investigated the protective effects of FAT against ultraviolet light B exposure (UVB; 30 mJ/cm2) in HaCaT (human keratinocyte) or Hs68 (human foreskin fibroblast) skin cells. FAT treatment was able to stimulate wound healing rate at the basal condition. FAT also favored the maintenance and/or improvement of extracellular matrix impairment caused by UVB irradiation through: 1) upregulation of procollagen Type-1 synthesis and secretion; 2) suppression of MMP-1 and elastase expression. FAT was able to play a role in the attenuation of inflammatory responses caused by UVB irradiation via upregulation of photo-protective hemeoxygease-1 and suppression of proinflammatory cyclooxygenase-2 expression. After further verification of the anti-photoaging potential of FAT, it could be utilized as an effective ingredient in anti-aging and anti-wrinkle cosmetics.
Full-Text
Key_wordAngelica tenuissima, photoaging, fermentation, ultraviolet light B, hemeoxygenase-1, extracellular matrix
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