2018 ; Vol.28-9: 1443~1446
|Author||Hae-Ji Lee, Su-Min Lim, Dong-Hyun Kim|
|Place of duty||Neutrobiota Research Center, Kyung Hee University, Seoul, 02447, Korea,Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Seoul, 02447, Korea|
|Title||Lactobacillus johnsonii CJLJ103 Attenuates Scopolamine-Induced Memory Impairment in Mice by Increasing BDNF Expression and Inhibiting NF-κB Activation|
J. Microbiol. Biotechnol.2018 ;
|Abstract||In the present study, we examined whether Lactobacillus johnsonii CJLJ103 (LJ) could alleviate
cholinergic memory impairment in mice. Oral administration of LJ alleviated scopolamineinduced
memory impairment in passive avoidance and Y-maze tasks. Furthermore, LJ
treatment increased scopolamine-suppressed BDNF expression and CREB phosphorylation in
the hippocampi of the brain, as well as suppressed TNF-α expression and NF-κB activation. LJ
also increased BDNF expression in corticosterone-stimulated SH-SY5Y cells and inhibited
NF-κB activation in LPS-stimulated microglial BV2 cells. However, LJ did not inhibit
acetylcholinesterase activity. These findings suggest that LJ, a member of human gut
microbiota, may mitigate cholinergic memory impairment by increasing BDNF expression and
inhibiting NF-κB activation.|
|Key_word||Lactobacillus johnsonii, memory impairment, BDNF, NF-κB|
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