2018 ; Vol.28-2: 218~226
|Author||Dae-Woon Choi, Sun Young Jung, Jisu Kang, Young-Do Nam, Seong-Il Lim, Ki Tae Kim, Hee Soon Shin|
|Place of duty||Food Biotechnology Program, Korea University of Science and Technology, Daejeon 34113, Republic of Korea,Division of Nutrition and Metabolism Research, Korea Food Research Institute, Wanju 55365, Republic of Korea|
|Title||Immune-Enhancing Effect of Nanometric Lactobacillus plantarum nF1 (nLp-nF1) in a Mouse Model of Cyclophosphamide-Induced Immunosuppression|
J. Microbiol. Biotechnol.2018 ;
|Abstract||Nanometric Lactobacillus plantarum nF1 (nLp-nF1) is a biogenics consisting of dead
L. plantarum cells pretreated with heat and a nanodispersion process. In this study, we
investigated the immune-enhancing effects of nLp-nF1 in vivo and in vitro. To evaluate the
immunostimulatory effects of nLp-nF1, mice immunosuppressed by cyclophosphamide (CPP)
treatment were administered with nLp-nF1. As expected, CPP restricted the immune response
of mice, whereas oral administration of nLp-nF1 significantly increased the total IgG in the
serum, and cytokine production (interleukin-12 (IL-12) and tumor necrosis factor alpha (TNF-α))
in bone marrow cells. Furthermore, nLp-nF1 enhanced the production of splenic cytokines
such as IL-12, TNF-α, and interferon gamma (IFN-γ). In vitro, nLp-nF1 stimulated the immune
response by enhancing the production of cytokines such as IL-12, TNF-α, and IFN-γ.
Moreover, nLp-nF1 given a food additive enhanced the immune responses when combined
with various food materials in vitro. These results suggest that nLp-nF1 could be used to
strengthen the immune system and recover normal immunity in people with a weak immune
system, such as children, the elderly, and patients.|
|Key_word||Nanometric Lactobacillus plantarum nF1, immune enhancement, interleukin-12, macrophage, immunoglobulin G, cyclophosphamide|
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