2018 ; Vol.28-1: 165~174
|Author||Hyungtaek Jeon, Yun Hee Kang, Seung-Min Yoo, Myung-Jin Park, Jong Bae Park, Seung-Hoon Lee, Myung-Shin Lee|
|Place of duty||Department of Microbiology and Immunology, Eulji University School of Medicine, Daejeon 34824, Republic of Korea|
|Title||Kaposi’s Sarcoma-Associated Herpesvirus Infection Modulates the Proliferation of Glioma Stem-Like Cells|
J. Microbiol. Biotechnol.2018 ;
|Abstract||Glioblastoma multiforme is the most lethal malignant brain tumor. Despite many intensive
studies, the prognosis of glioblastoma multiforme is currently very poor, with a median
overall survival duration of 14 months and 2-year survival rates of less than 10%. Although
viral infections have been emphasized as potential cofactors, their influences on pathways that
support glioblastoma progression are not known. Some previous studies indicated that human
Kaposi’s sarcoma-associated herpesvirus (KSHV) was detected in healthy brains, and its
microRNA was also detected in glioblastoma patients’ plasma. However, a direct link between
KSHV infection and glioblastoma is currently not known. In this study, we infected
glioblastoma cells and glioma stem-like cells (GSCs) with KSHV to establish an in vitro cell
model for KSHV-infected glioblastoma cells and glioma stem-like cells in order to identify
virologic outcomes that overlap with markers of aggressive disease. Latently KSHV-infected
glioblastoma cells and GSCs were successfully established. Additionally, using these cell
models, we found that KSHV infection modulates the proliferation of glioma stem-like cells.|
|Key_word||KSHV, HHV-8, glioblastoma, glioma stem-like cell, proliferation|
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