Journal of Microbiology and Biotechnology
The Korean Society for Microbiology and Biotechnology publishes the Journal of Microbiology and Biotechnology.

2017 ; Vol.27-10: 1727~1735

AuthorSangmin Kang, Jinjong Myoung
Place of dutyKorea Zoonosis Research Institute, Chonbuk National University, Iksan 54531, Republic of Korea
TitleHost Innate Immunity against Hepatitis E Virus and Viral Evasion Mechanisms
PublicationInfo J. Microbiol. Biotechnol.2017 ; Vol.27-10
AbstractHepatitis E virus (HEV) infections cause epidemic or sporadic acute hepatitis, which are mostly self-limiting. However, viral infection in immunocompromised patients and pregnant women may result in serious consequences, such as chronic hepatitis and liver damage, mortality of the latter of which reaches up to 20-30%. Type I interferon (IFN)-induced antiviral immunity is known to be the first-line defense against virus infection. Upon HEV infection in the cell, the virus genome is recognized by pathogen recognition receptors, leading to rapid activation of intracellular signaling cascades. Expression of type I IFN triggers induction of a barrage of IFN-stimulated genes, helping the cells cope with viral infection. Interestingly, some of the HEV-encoded genes seem to be involved in disrupting signaling cascades for antiviral immune responses, and thus crippling cytokine/chemokine production. Antagonistic mechanisms of type I IFN responses by HEV have only recently begun to emerge, and in this review, we summarize known HEV evasion strategies and compare them with those of other hepatitis viruses.
Full-Text
Key_wordHepatitis E virus, immune evasion, innate immunity, interferon
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