2017 ; Vol.27-2: 242~250
|Author||Jongwook Kim, Mi-Bo Kim, Jun Gon Yun, Jae Kwan Hwang|
|Place of duty||Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Republic of Korea|
|Title||Protective Effects of Standardized Siegesbeckia glabrescens Extract and Its Active Compound Kirenol against UVB-Induced Photoaging through Inhibition of MAPK/NF-κB Pathways|
J. Microbiol. Biotechnol.2017 ;
|Abstract||Anti-photoaging effects of standardized Siegesbeckia glabrescens extract (SGE) and its major
active compound kirenol were investigated using Hs68 human dermal fibroblasts and hairless
mice, respectively. UVB-irradiated hairless mice that received oral SGE (600 mg/kg/day)
showed reduced wrinkle formation and skinfold thickness compared with the UVB-irradiated
control. Furthermore, SGE treatment increased the mRNA levels of collagen synthesis genes
(COL1A1, COL3A1, COL4A1, and COL7A1) and activated antioxidant enzyme (catalase),
while suppressing matrix metalloproteinase (MMP-2, -3, -9, and -13) expression. In Hs68
fibroblasts, kirenol also significantly suppressed MMP expression while increasing the
expression of COL1A1, COL3A1, and COL7A1. Collectively, our data demonstrate that both
SGE and kirenol attenuated UVB-induced photoaging in hairless mice and fibroblasts through
inhibition of the mitogen-activated protein kinases and nuclear factor kappa B pathways,
suggesting that SGE has potential to serve as a natural anti-photoaging nutraceutical.|
|Key_word||Kirenol, MAPK/NF-κB pathways, photoaging, Siegesbeckia glabrescens|
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