2016 ; Vol.26-1: 61~65
|Author||Mi-Sun Kim, Woo-Chang Shin, Dong-Kyoon Kang, Ho-Yong Sohn|
|Place of duty||Department of Food and Nutrition, Andong National University, Andong 760-749, Republic of Korea|
|Title||Anti-Thrombosis Activity of Sinapic Acid Isolated from the Lees of Bokbunja Wine|
J. Microbiol. Biotechnol.2016 ;
|Abstract||From the lees of bokbunja wine (LBW) made from Rubus coreanus Miquel, we have identified
six compounds (1: trans-4-hydroxycinnamic acid; 2: trans-4-hydroxy-3-methoxycinnamic acid;
3: 3,4-dihydroxycinnamic acid; 4: 4-hydroxy-3-methoxybenzoic acid; 5: 3,5-dimethoxy-4-
hydroxybenzoic acid; and 6: 3,5-dimethoxy-4-hydroxycinnamic acid (sinapic acid)) through
silica gel chromatography and UHPLC-MS. The compounds 1-6 showed strong anticoagulation
and platelet aggregation inhibitory activities without hemolytic effect against
human red blood cells. To date, this is the first report of the in vitro anti-thrombosis activity of
sinapic acid. Our results suggest that different cinnamic and benzoic acid derivatives are
closely linked to the anti-thrombosis activity of LBW, and sinapic acid could be developed as a
promising anti-thrombosis agent.|
|Key_word||Anti-thrombosis Activity, Sinapic Acid, lees of bokbunja wine, Rubus coreanus MIQ|
Balaji C, Muthukumaran J, Nalini N. 2014. Chemopreventive effect of sinapc acid on 1,2-dimethylhydrazine-induced experimental rat colon carcinogenesis. Hum. Exp. Toxicol. 33: 1253-1268.
Cherng YG, Tsai CC, Chung HH, Lai YW, Kuo SC, Cheng JT. 2013. Antihyperglycemic action of sinapic acid in diabetic rats. J. Agric. Food Chem. 61: 12053-12059.
Fabre N, Urizzi P, Souchard JP, Fréchard A, Claparols C, Fourasté I, Moulis C. 2000. An antioxidant sinapic acid ester isolated from Iberis amara. Fitoterapia 71: 425-428
Galano A, Francisco-Marquez M, Alvarez-Idaboy JR. 2011. Mechanism and kinetics studies on the antioxidant activity of sinapinic acid. Phys. Chem. Chem. Phys. 13: 11199-11205.
Karakida F, Ikeyya Y, Tsunakawa M, Yamaguchi T, Ikarashi Y, Takeda S, Aburada M. 2007. Cerebral protective and cognition-improving effects of sinapic acid in rodents. Biol. Pharm. Bull. 30: 514-519.
Kim DH, Yoon BH, Jung WY, Kim JM, Park SJ, Park DH, et al. 2010. Sinapic acid attenuates kainic acid-induced hippocampal neuronal damage in mice. Neuropharmacology 59: 20-30.
Kim MS, Kang DK, Shin WC, Sohn HY. 2015. Anti-microbial, anti-oxidant and anti-thrombosis activity of lees of bokbunjawine (Rubus coreanus Miquel). J. Life Sci. 25: 757-764.
Ku SK, Bae JS. 2014. Antiplatelet and antithrombotic activities of purourogallin in vitro and in vivo. BMB Rep. 47: 376-381.
Lee HE, Kim DH, Park SJ, Kim JM, Lee YW, Jung JM, et al. 2012. Neuroprotective effect of sinapic acid in a mouse model of amyloid β1-42 protein-induced Alzheimer’s disease. Pharmacol. Biochem. Behav. 103: 260-266.
Ni iforovi N, Abramovic H. 2014. Sinapic acid and its derivatives: natural sources and bioactivity. Comp. Rev. Food Sci. Food Safety 13: 34-51.
Pari L, Mohamed Jalaludeen A. 2011. Protective role of sinipic acid against arsenic induced toxicity in rats. Chem. Biol. Interact. 194: 40-47.
Roy SJ, Stanely P, Prince M. 2012. Protective effects of sinapic acid on lysosomal dysfunction in isoproterenol induced myocardial infarcted rats. Food Chem. Toxicol. 50: 3984-3989.
Sedej L, Saka M, Mandic A, Misan A, Thubas V, Canadanovic-Brunet J. 2012. Buckwheat (Fagopyrum esculentum Moench) grain and fractions: antioxidant compounds and activities. J. Food Sci. 77: C954-C959.
Sohn HY, Kwon CS, Son KH. 2010. Fungicidal effect of prenylated flavonol, papyriflavonol A, isolated from Broussonetia papyrifera (L.) Vent. against Candida albicans. J. Microbiol. Biotechnol. 20: 1397-1402.
Sun XL, Ito H, Masuoka T, Kamei C, Hatano T. 2007. Effect of Polygala tenuifolia root extract on scopolamine-induced impairment of rat spatial cognition in an eight-arm radial maze task. Biol. Pharm. Bull. 30: 1727-1731.
Tesaki S, Tanabe S, Ono H, Fukushi E, Kawabata J, Watanabe M. 1998. 4-Hydroxy-3-nitrophenylacetic and sinapic acids as antibacterial compounds from mustard seeds. Biosci. Biotechnol. Biochem. 62: 998-1000.
Thangarasu Silambarasan T, Manivannan J, Priya MK, Suganya N, Chatterjee S, Raja B. 2015. Sinapic acid protects heart against ischemia/reperfusion injury and H9c2 cardiomyoblast cells against oxidative stress. Biochem. Biophy. Res. Commun. 456: 853-859.
Yoon BH, Jung JW, Lee JJ, Cho YW, Jang CG, Jin CB, et al. 2007. Anxiolytic-like effects of sinapic acid in mice. Life Sci. 81: 234-240.
Yun KJ, Koh DJ, Kim SH, Park SJ, Ryu JH, Kim DG, et al. 2008. Anti-inflammatory effects of sinapic acid through the suppression of inducible nitric oxide synthase, cyclooxygase2, and proinflammatory cytokines expressions via nuclear factor-kappaB inactivation. J. Agric. Food Chem. 56: 10265-10272.
Zeng X, Zheng J, Fu C, Su H, Sun X, Zhang X, et al. 2013. A newly synthesized sinapic acid derivative inhibits endothelial activation in vitro and in vivo. Mol. Pharmacol. 83: 1099-1108
Zou Y, Kim AR, Kim JE, Choi JS, Chung HY. 2002. Peroxynitrite scavenging activity of sinapic acid (3,5-dimethoxy4-hydroxycinnamic acid) isolated from Brassica juncea. J. Agric. Food Chem. 50: 5884-5890.