Journal of Microbiology and Biotechnology
The Korean Society for Microbiology and Biotechnology publishes the Journal of Microbiology and Biotechnology.

2015 ; Vol.25-10: 1697~1701

AuthorKyoung Jun Han, Na-Kyoung Lee, Hoon Park, Hyun-Dong Paik
Place of dutyDepartment of Food Science and Biotechnology of Animal Resources, Konkuk University, Seoul 143-701, Republic of Korea
TitleAnticancer and Anti-Inflammatory Activity of Probiotic Lactococcus lactis NK34
PublicationInfo J. Microbiol. Biotechnol.2015 ; Vol.25-10
AbstractThe anticancer and anti-inflammatory activities of probiotic Lactococcus lactis NK34 were demonstrated. Treatment of cancer cells such as SK-MES-1, DLD-1, HT-29, LoVo, AGS, and MCF-7 cells with 106 CFU/well of L. lactis NK34 resulted in strong inhibition of proliferation (>77% cytotoxicity, p < 0.05). The anti-inflammatory activity of L. lactis NK34 was also demonstrated in lipopolysaccharide-induced RAW 264.7 cells, where the production of nitric oxide and proinflammatory cytokines (tumor necrosis factor-α, interleukin-18, and cyclooxygenase-2) was reduced. These results suggest that L. lactis NK34 could be used as a probiotic microorganism to inhibit the proliferation of cancer cells and production of proinflammatory cytokines.
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Key_wordProbiotic, Lactococcus lactis, anticancer activity, anti-inflammatory activity,, cytokine



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